概述

  • 产品名称Anti-IL16抗体[59]
    参阅全部 IL16 一抗
  • 描述
    小鼠单克隆抗体[59] to IL16
  • 特异性MAb 59 exhibits no detectable cross-reacting with human albumin serum, Bovine albumin serum and other human cytokines or growth factors tested such as IL-1-beta, IL-8, IL-7 MCAF, TGF-beta-1, EGF, bFGF, GM-CSF, M-CSF, TNF-alpha.
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Purified recombinant human IL-16.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: None
    Constituents: 0.01M PBS, pH 7.2
  • Concentration information loading...
  • 纯度Protein G purified
  • 克隆单克隆
  • 克隆编号59
  • 骨髓瘤Sp2/0-Ag14
  • 同种型IgG2b
  • 轻链类型kappa
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab18673 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent dilution.
WB Use a concentration of 2.5 µg/ml. Predicted molecular weight: 67 kDa.

靶标

  • 功能Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.
    Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane.
    Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
  • 组织特异性Isoform 3 is expressed in hemopoietic tissues, such as resting T-cells, but is undetectable during active T cell proliferation.
  • 序列相似性Contains 4 PDZ (DHR) domains.
  • 翻译后修饰Isoform 3 is synthesized as a chemo-attractant inactive precursor in hemopoietic tissues and is proteolytically cleaved by caspase-3 to yield IL-16.
  • 细胞定位Cytoplasm; Cytoplasm. Nucleus and Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • HGNC:5980 antibody
    • HsT19289 antibody
    • IL-16 antibody
    • IL16 antibody
    • IL16_HUMAN antibody
    • Interleukin 16 precursor antibody
    • Interleukin-16 antibody
    • LCF antibody
    • Lymphocyte chemoattractant factor antibody
    • Neuronal interleukin 16 antibody
    • NIL16 antibody
    • prIL 16 antibody
    • PrIL16 antibody
    • Prointerleukin 16 antibody
    see all

Anti-IL16 antibody [59] (ab18673)参考文献

ab18673 has not yet been referenced specifically in any publications.

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