Anti-IL16抗体[1F12D7] (ab59010)

概述

  • 产品名称Anti-IL16抗体[1F12D7]
    参阅全部 IL16 一抗
  • 描述
    小鼠单克隆抗体[1F12D7] to IL16
  • 特异性This antibody has been shown to recognize recombinant IL16.
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Recombinant Fragment
    预测可用于: Human
  • 免疫原

    Ni-NTA purified recombinant human IL16 expressed in E. Coli strain BL21 (DE3).

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Concentration information loading...
  • 纯度Protein A purified
  • 克隆单克隆
  • 克隆编号1F12D7
  • 同种型IgG1
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab59010 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent dilution.
WB 1/500 - 1/1000. Detects a band of approximately 20 kDa (predicted molecular weight: 67 kDa). This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.

靶标

  • 功能Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.
    Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane.
    Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
  • 组织特异性Isoform 3 is expressed in hemopoietic tissues, such as resting T-cells, but is undetectable during active T cell proliferation.
  • 序列相似性Contains 4 PDZ (DHR) domains.
  • 翻译后修饰Isoform 3 is synthesized as a chemo-attractant inactive precursor in hemopoietic tissues and is proteolytically cleaved by caspase-3 to yield IL-16.
  • 细胞定位Cytoplasm; Cytoplasm. Nucleus and Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • HGNC:5980 antibody
    • HsT19289 antibody
    • IL-16 antibody
    • IL16 antibody
    • IL16_HUMAN antibody
    • Interleukin 16 precursor antibody
    • Interleukin-16 antibody
    • LCF antibody
    • Lymphocyte chemoattractant factor antibody
    • Neuronal interleukin 16 antibody
    • NIL16 antibody
    • prIL 16 antibody
    • PrIL16 antibody
    • Prointerleukin 16 antibody
    see all

Anti-IL16 antibody [1F12D7] 图像

Anti-IL16 antibody [1F12D7] (ab59010)参考文献

ab59010 has not yet been referenced specifically in any publications.

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