Anti-IL15RA抗体[RM0103-6C38] (ab86486)

概述

  • 产品名称Anti-IL15RA抗体[RM0103-6C38]
    参阅全部 IL15RA 一抗
  • 描述
    大鼠单克隆抗体[RM0103-6C38] to IL15RA
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Recombinant fragment, corresponding to the extracellular domain of Mouse IL15RA

性能

应用

Our Abpromise guarantee covers the use of ab86486 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: 1/500 - 1/1000. Predicted molecular weight: 28 kDa (isoform 1).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Receptor for interleukin-15. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves STAT3, STAT5, STAT6, JAK2 (By similarity) and SYK.
    • 组织特异性Isoform 1, isoform 3, isoform 4, isoform 5, isoform 6, isoform 7, isoform 8 and isoform 9 are widely expressed. Expressed in fetal brain with higher expression in the hippocampus and cerebellum than in cortex and thalamus. Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures.
    • 序列相似性Contains 1 Sushi (CCP/SCR) domain.
    • 翻译后修饰A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor. The cleavage involves ADAM17/TACE (By similarity). It also binds IL-15 and thus interferes with IL-15 binding to the membrane receptor.
      Phosphorylated by activated SYK.
      N-glycosylated and O-glycosylated.
    • 细胞定位Secreted > extracellular space; Membrane. Nucleus membrane. Mainly found associated with the nuclear membrane and Endoplasmic reticulum membrane. Golgi apparatus membrane. Cytoplasmic vesicle membrane. Membrane. Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • AA690181 antibody
      • CD215 antibody
      • I15RA_HUMAN antibody
      • IL 15R alpha antibody
      • IL-15 receptor subunit alpha antibody
      • IL-15R-alpha antibody
      • IL-15RA antibody
      • Il15ra antibody
      • Interleukin 15 receptor alpha antibody
      • Interleukin 15 receptor subunit alpha antibody
      • MGC104179 antibody
      • sIL-15 receptor subunit alpha antibody
      • sIL-15R-alpha antibody
      • sIL-15RA antibody
      • Soluble interleukin 15 receptor subunit alpha antibody
      • Soluble interleukin-15 receptor subunit alpha antibody
      see all

    Anti-IL15RA antibody [RM0103-6C38] (ab86486)参考文献

    This product has been referenced in:
    • Takashima A  et al. Uterine natural killer cells severely decrease in number at gestation day 6 in mice. Biol Reprod 89:101 (2013). WB ; Mouse . Read more (PubMed: 24025738) »
    • Chenoweth MJ  et al. IL-15 can signal via IL-15Ra, JNK, and NF-?B to drive RANTES production by myeloid cells. J Immunol 188:4149-57 (2012). Blocking ; Mouse . Read more (PubMed: 22447977) »

    See all 2 Publications for this product

    Product Wall

    Thank you for your phone call. Unfortunately, I was unable to obtain any more specific information about the immunogen other than that it is the extracellular domain (33-205aa) of mouse IL-15R alpha (Q60819). I hope this helps, please let me know if yo...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"