Anti-IL15RA抗体[MM0369-5M53] (ab89894)

概述

  • 产品名称Anti-IL15RA抗体[MM0369-5M53]
    参阅全部 IL15RA 一抗
  • 描述
    小鼠单克隆抗体[MM0369-5M53] to IL15RA
  • 特异性ab89894 detects IL15RA.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment corresponding to the extracellular domain of Human IL15RA.

性能

应用

Our Abpromise guarantee covers the use of ab89894 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 28 kDa. WB ab89894 has been tested only against the immunogen and negative results were obtained in ELISA against mouse IL15RA.

靶标

  • 功能Receptor for interleukin-15. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves STAT3, STAT5, STAT6, JAK2 (By similarity) and SYK.
  • 组织特异性Isoform 1, isoform 3, isoform 4, isoform 5, isoform 6, isoform 7, isoform 8 and isoform 9 are widely expressed. Expressed in fetal brain with higher expression in the hippocampus and cerebellum than in cortex and thalamus. Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures.
  • 序列相似性Contains 1 Sushi (CCP/SCR) domain.
  • 翻译后修饰A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor. The cleavage involves ADAM17/TACE (By similarity). It also binds IL-15 and thus interferes with IL-15 binding to the membrane receptor.
    Phosphorylated by activated SYK.
    N-glycosylated and O-glycosylated.
  • 细胞定位Secreted > extracellular space; Membrane. Nucleus membrane. Mainly found associated with the nuclear membrane and Endoplasmic reticulum membrane. Golgi apparatus membrane. Cytoplasmic vesicle membrane. Membrane. Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AA690181 antibody
    • CD215 antibody
    • I15RA_HUMAN antibody
    • IL 15R alpha antibody
    • IL-15 receptor subunit alpha antibody
    • IL-15R-alpha antibody
    • IL-15RA antibody
    • Il15ra antibody
    • Interleukin 15 receptor alpha antibody
    • Interleukin 15 receptor subunit alpha antibody
    • MGC104179 antibody
    • sIL-15 receptor subunit alpha antibody
    • sIL-15R-alpha antibody
    • sIL-15RA antibody
    • Soluble interleukin 15 receptor subunit alpha antibody
    • Soluble interleukin-15 receptor subunit alpha antibody
    see all

Anti-IL15RA antibody [MM0369-5M53] (ab89894)参考文献

ab89894 has not yet been referenced specifically in any publications.

Product Wall

Application Western blot
Sample Human Recombinant protein (hIL-15ra recombinant protein transduced into EL ce)
Loading amount 15 µg
Specification hIL-15ra recombinant protein transduced into EL ce
Treatment BME
Gel Running Conditions Reduced Denaturing
Blocking step Milk as blocking agent for 10 hour(s) and 0 minute(s) · Concentration: 3% · Temperature: 4°C
Username

Gong Yun

Verified customer

提交于 Jan 10 2011

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"