概述

  • 产品名称Anti-IL12RB1抗体
    参阅全部 IL12RB1 一抗
  • 描述
    兔多克隆抗体to IL12RB1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment, corresponding to a region within amino acids 57-458 of Human IL12RB1 (NP_005526).

  • 阳性对照
    • A431 whole cell lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

相关产品

应用

Our Abpromise guarantee covers the use of ab96517 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 73 kDa.

靶标

  • 功能Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.
  • 疾病相关Defects in IL12RB1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]; also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity, whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.
  • 序列相似性Belongs to the type I cytokine receptor family. Type 2 subfamily.
    Contains 5 fibronectin type-III domains.
  • 结构域The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CD212 antibody
    • cluster of differentiation 212 antibody
    • I12R1_HUMAN antibody
    • IL-12 receptor beta component antibody
    • IL-12 receptor subunit beta-1 antibody
    • IL-12R subunit beta-1 antibody
    • IL-12R-beta-1 antibody
    • IL-12RB1 antibody
    • IL12 receptor beta component antibody
    • IL12RB antibody
    • Il12rb1 antibody
    • IMD3 antibody
    • IMD30 antibody
    • Interleukin 12 receptor beta 1 chain antibody
    • Interleukin 12 receptor subunit beta 1 antibody
    • Interleukin-12 receptor subunit beta-1 antibody
    • MGC34454 antibody
    see all

Anti-IL12RB1 antibody 图像

  • Anti-IL12RB1 antibody (ab96517) at 1/1000 dilution + A431 whole cell lysate at 30 µg

    Predicted band size : 73 kDa

Anti-IL12RB1 antibody (ab96517)参考文献

This product has been referenced in:
  • Quiniou C  et al. Specific targeting of the IL-23 receptor, using a novel small peptide noncompetitive antagonist, decreases the inflammatory response. Am J Physiol Regul Integr Comp Physiol 307:R1216-30 (2014). Read more (PubMed: 25354400) »

See 1 Publication for this product

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