Anti-IL12 p40抗体- Carboxyterminal end (ab66463)


  • 产品名称Anti-IL12 p40抗体- Carboxyterminal end
    参阅全部 IL12 p40 一抗
  • 描述
    兔多克隆抗体to IL12 p40 - Carboxyterminal end
  • 特异性This antibody reacts specifically with the 40kDa IL12 p40 protein
  • 经测试应用适用于: IHC-P, WBmore details
  • 种属反应性
    与反应: Pufferfish (Fugu)
  • 免疫原

    Synthetic peptide derived from the C terminal domain of IL12 p40


  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: Whole serum
  • 纯度Whole antiserum
  • 克隆多克隆
  • 同种型IgG
  • 研究领域


Our Abpromise guarantee covers the use of ab66463 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use at an assay dependent concentration.
WB 1/500 - 1/5000. Predicted molecular weight: 40 kDa.


  • 功能Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.
    Associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
  • 疾病相关Defects in IL12B are a cause of mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]; also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity, whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.
    Genetic variations in IL12B are a cause of susceptibility to psoriasis type 11 (PSORS11) [MIM:612599]. Psoriasis is a common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.
  • 序列相似性Belongs to the type I cytokine receptor family. Type 3 subfamily.
    Contains 1 fibronectin type-III domain.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • 翻译后修饰Known to be C-mannosylated in the recombinant protein; it is not yet known for sure if the wild-type protein is also modified.
  • 细胞定位Secreted.
  • Information by UniProt
  • 别名
    • CLMF antibody
    • CLMF p40 antibody
    • CLMF2 antibody
    • Cytotoxic lymphocyte maturation factor 40 kDa subunit antibody
    • IL 12 subunit p40 antibody
    • IL 12B antibody
    • IL-12 subunit p40 antibody
    • IL-12B antibody
    • IL12 subunit p40 antibody
    • IL12B antibody
    • IL12B_HUMAN antibody
    • interleukin 12 beta chain antibody
    • Interleukin 12 p40 antibody
    • Interleukin 12 subunit beta antibody
    • Interleukin 12B antibody
    • Interleukin-12 subunit beta antibody
    • natural killer cell stimulatory factor 40 kD subunit antibody
    • NK cell stimulatory factor chain 2 antibody
    • NKSF antibody
    • NKSF2 antibody
    • p40 antibody
    see all

Anti-IL12 p40 antibody - Carboxyterminal end (ab66463)参考文献

ab66463 has not yet been referenced specifically in any publications.

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