Anti-IL10RB抗体[MM0360-8R24] (ab89884)


  • 产品名称Anti-IL10RB抗体[MM0360-8R24]
    参阅全部 IL10RB 一抗
  • 描述
    小鼠单克隆抗体[MM0360-8R24] to IL10RB
  • 经测试应用适用于: Flow Cyt, WB, Neutralisingmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant Human IL10RB extracellular domain.



Our Abpromise guarantee covers the use of ab89884 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use 1µg for 106 cells. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
WB 1/500 - 1/2000. Predicted molecular weight: 37 kDa.
Neutralising Use at an assay dependent concentration.


  • 功能Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IL29.
  • 疾病相关Defects in IL10RB are the cause of inflammatory bowel disease type 25 (IBD25) [MIM:612567]. It is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
  • 序列相似性Belongs to the type II cytokine receptor family.
    Contains 2 fibronectin type-III domains.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Cd210 antibody
    • CDw210b antibody
    • CRF2 4 antibody
    • CRF2-4 antibody
    • CRFB4 antibody
    • Cytokine receptor class II antibody
    • Cytokine receptor class II CRF2 4 antibody
    • Cytokine receptor class-II member 4 antibody
    • Cytokine receptor family 2 member 4 antibody
    • Cytokine receptor family II member 4 antibody
    • D21S58 antibody
    • D21S66 antibody
    • I10R2_HUMAN antibody
    • IL-10 receptor subunit beta antibody
    • IL-10R subunit 2 antibody
    • IL-10R subunit beta antibody
    • IL-10R2 antibody
    • IL-10RB antibody
    • IL10R2 antibody
    • IL10RB antibody
    • Interleukin 10 receptor beta antibody
    • Interleukin-10 receptor subunit 2 antibody
    • Interleukin-10 receptor subunit beta antibody
    see all

Anti-IL10RB antibody [MM0360-8R24] 图像

  • Overlay histogram showing Jurkat cells stained with ab89884 (red line). The cells were fixed with 80% methanol (5 min) and incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab89884, 1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. Please note that Abcam do not have any data for use of this antibody on non-fixed cells. We welcome any customer feedback.

Anti-IL10RB antibody [MM0360-8R24] (ab89884)参考文献

ab89884 has not yet been referenced specifically in any publications.

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