Anti-IKZF3抗体(ab56867)

概述

性能

应用

Our Abpromise guarantee covers the use of ab56867 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.
    • 组织特异性Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus.
    • 序列相似性Belongs to the Ikaros C2H2-type zinc-finger protein family.
      Contains 6 C2H2-type zinc fingers.
    • 翻译后修饰Phosphorylation on tyrosine residues induced by IL2 is required for dissociation from HRAS and nuclear translocation of IKZF3 in T-cells. Phosphorylation on tyrosine residues induced by IL4 is required for dissociation from Bcl-X(L) in T-cells.
    • 细胞定位Nucleus. Cytoplasm.
    • Information by UniProt
    • 数据库链接
    • 别名
      • AIO antibody
      • Aiolos antibody
      • IKAROS family zinc finger 3 (Aiolos) antibody
      • IKAROS family zinc finger 3 antibody
      • Ikaros family zinc finger protein 3 antibody
      • IKZF 3 antibody
      • IKZF3 antibody
      • IKZF3_HUMAN antibody
      • zinc finger DNA binding protein Aiolos antibody
      • Zinc finger protein Aiolos antibody
      • Zinc finger protein subfamily 1A 3 (Aiolos) antibody
      • Zinc finger protein subfamily 1A 3 antibody
      • Zinc finger protein subfamily 1A, member 3 antibody
      • ZNFN1A3 antibody
      see all

    Anti-IKZF3 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab56867 IKZF3 antibody at 1ug/ml. Predicted band size of immunogen is 82 kDa

    Anti-IKZF3 antibody (ab56867)参考文献

    ab56867 has not yet been referenced specifically in any publications.

    Product Wall

    I now have the information from the source of the Anti-IKZF3 antibody (ab56867). Unfortunately, epitope mapping has as yet not been performed with this antibody. We cannot therefore predict which isoforms (apart from isoform 1 which the antibody was ra...

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    Thank you for contacting us and your interest in our products.

    In regards to the Anti-IKZF3 antibody (ab56867), the antibody is raised against the full lenght recombinantly expressed human protein. From performing sequence alignment, which is...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"