Anti-IKB zeta抗体(ab155142)
Key features and details
- Rabbit polyclonal to IKB zeta
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-IKB zeta抗体
参阅全部 IKB zeta 一抗 -
描述
兔多克隆抗体to IKB zeta -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Rat, Cow -
免疫原
Recombinant fragment, corresponding to a region within amino acids 303-609 of Human IKB zeta (UniProt Q9BYH8).
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阳性对照
- HeLa nuclear lysate.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab155142于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/3000. Predicted molecular weight: 78 kDa.
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说明 |
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WB
1/500 - 1/3000. Predicted molecular weight: 78 kDa. |
靶标
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功能
Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis. -
组织特异性
Expressed at high levels in peripheral blood leukocytes and lung, at moderate levels in liver, placenta, and at low levels in spleen, kidney, skeletal muscle and heart. -
序列相似性
Contains 7 ANK repeats. -
细胞定位
Nucleus. Aggregated in dot-like structures. Colocalizes with NCOR2. - Information by UniProt
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数据库链接
- Entrez Gene: 282713 Cow
- Entrez Gene: 64332 Human
- Entrez Gene: 304005 Rat
- Omim: 608004 Human
- SwissProt: Q9BE45 Cow
- SwissProt: Q9BYH8 Human
- Unigene: 319171 Human
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别名
- FLJ30225 antibody
- FLJ34463 antibody
- I-kappa-B-zeta antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab155142 被引用在 2 文献中.
- Liu S et al. IL-17A synergistically enhances TLR3-mediated IL-36? production by keratinocytes: A potential role in injury-amplified psoriatic inflammation. Exp Dermatol 28:233-239 (2019). PubMed: 30614571
- Zhou K et al. Potential role of TET2 in gastric cancer cisplatin resistance. Pathol Res Pract 215:152637 (2019). PubMed: 31570278