概述

  • 产品名称Anti-IKB zeta抗体
    参阅全部 IKB zeta 一抗
  • 描述
    兔多克隆抗体to IKB zeta
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Rat, Sheep, Rabbit, Goat, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within C-terminal amino acids 679-728 (VRLLMRKGAD PSTRNLENEQ PVHLVPDGPV GEQIRRILKG KSIQQRAPPY)of Mouse IKB zeta (NP_085115).

  • 阳性对照
    • Mouse Brain Lysate

应用

Our Abpromise guarantee covers the use of ab113629 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 78 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis.
  • 组织特异性Expressed at high levels in peripheral blood leukocytes and lung, at moderate levels in liver, placenta, and at low levels in spleen, kidney, skeletal muscle and heart.
  • 序列相似性Contains 7 ANK repeats.
  • 细胞定位Nucleus. Aggregated in dot-like structures. Colocalizes with NCOR2.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FLJ30225 antibody
    • FLJ34463 antibody
    • I-kappa-B-zeta antibody
    • Ikappa B zeta antibody
    • IkappaB zeta antibody
    • IkappaBzeta antibody
    • IkB-zeta antibody
    • IKBZ antibody
    • IKBZ_HUMAN antibody
    • IKBzeta antibody
    • IL-1 inducible nuclear ankyrin-repeat protein antibody
    • INAP antibody
    • MAIL antibody
    • MAIL protein antibody
    • Molecule possessing ankyrin repeats induced by lipopolysaccharide antibody
    • NF-kappa-B inhibitor zeta antibody
    • NFKBIZ antibody
    • Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor zeta antibody
    see all

Anti-IKB zeta antibody 图像

  • Anti-IKB zeta antibody (ab113629) at 1 µg/ml + Mouse Brain Lysate at 10 µg

    Predicted band size : 78 kDa

Anti-IKB zeta antibody (ab113629)参考文献

ab113629 has not yet been referenced specifically in any publications.

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