Anti-IkB beta (phospho T19)抗体(ab63510)

概述

  • 产品名称Anti-IkB beta (phospho T19)抗体
    参阅全部 IKB beta 一抗
  • 描述
    兔多克隆抗体to IkB beta (phospho T19)
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic phosphopeptide derived from human IkB beta around the phosphorylation site of threonine 19

  • 常规说明


    Detects IkB beta only when phosphorylated at threonine 19.

性能

应用

Our Abpromise guarantee covers the use of ab63510 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 38 kDa (predicted molecular weight: 38 kDa).
ELISA 1/5000.

靶标

  • 功能Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
  • 组织特异性Expressed in all tissues examined.
  • 序列相似性Belongs to the NF-kappa-B inhibitor family.
    Contains 6 ANK repeats.
  • 翻译后修饰Phosphorylated by RPS6KA1; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation.
  • 细胞定位Cytoplasm. Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • I kappa B beta antibody
    • I-kappa-B-beta antibody
    • IkappaBbeta antibody
    • IKB beta antibody
    • IkB-B antibody
    • IkB-beta antibody
    • IKBB antibody
    • IKBB_HUMAN antibody
    • IkBbeta antibody
    • NF kappa BIB antibody
    • NF-kappa-B inhibitor beta antibody
    • NF-kappa-BIB antibody
    • Nfkbib antibody
    • Thyroid receptor interacting protein 9 antibody
    • Thyroid receptor-interacting protein 9 antibody
    • TR interacting protein 9 antibody
    • TR-interacting protein 9 antibody
    • TRIP-9 antibody
    • TRIP9 antibody
    see all

Anti-IkB beta (phospho T19) antibody (ab63510)参考文献

ab63510 has not yet been referenced specifically in any publications.

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Thank you for your inquiry.

I heard back from the lab that the immunogen specificity is for T19. Swiss Prot (http://www.uniprot.org/uniprot/Q15653#ref1) also mentions a sequence conflict, based on experimental info, that marks 19: S -> T (...

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