Anti-IKB beta (phospho T19)抗体(ab63510)
Key features and details
- Rabbit polyclonal to IKB beta (phospho T19)
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
-
产品名称
Anti-IKB beta (phospho T19)抗体
参阅全部 IKB beta 一抗 -
描述
兔多克隆抗体to IKB beta (phospho T19) -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide corresponding to Human IKB beta (phospho T19).
Database link: Q15653 -
常规说明
Detects IkB beta only when phosphorylated at threonine 19.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride -
Concentration information loading...
-
纯度
Immunogen affinity purified -
纯化说明
The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site -
Primary antibody说明
Detects IkB beta only when phosphorylated at threonine 19. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab63510于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
WB |
1/500 - 1/1000. Predicted molecular weight: 37 kDa.
|
说明 |
---|
WB
1/500 - 1/1000. Predicted molecular weight: 37 kDa. |
靶标
-
功能
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation. -
组织特异性
Expressed in all tissues examined. -
序列相似性
Belongs to the NF-kappa-B inhibitor family.
Contains 6 ANK repeats. -
翻译后修饰
Phosphorylated by RPS6KA1; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation. -
细胞定位
Cytoplasm. Nucleus. - Information by UniProt
-
数据库链接
- Entrez Gene: 4793 Human
- Omim: 604495 Human
- SwissProt: Q15653 Human
- Unigene: 9731 Human
-
别名
- I kappa B beta antibody
- I-kappa-B-beta antibody
- IkappaBbeta antibody
see all
数据表及文件
-
SDS download
-
Datasheet download
文献 (0)
ab63510 尚未被引用在任何文献中。