概述

描述

  • 性质
    Synthetic

相关产品

技术指标

Our Abpromise guarantee covers the use of ab7548 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

    Inhibition Assay

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: 0.01% Sodium Azide

常规信息

  • 别名
    • I kappa B beta
    • I-kappa-B-beta
    • IkappaBbeta
    • IKB beta
    • IkB-B
    • IkB-beta
    • IKBB
    • IKBB_HUMAN
    • IkBbeta
    • NF kappa BIB
    • NF-kappa-B inhibitor beta
    • NF-kappa-BIB
    • Nfkbib
    • Thyroid receptor interacting protein 9
    • Thyroid receptor-interacting protein 9
    • TR interacting protein 9
    • TR-interacting protein 9
    • TRIP-9
    • TRIP9
    see all
  • 功能
    Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
  • 组织特异性
    Expressed in all tissues examined.
  • 序列相似性
    Belongs to the NF-kappa-B inhibitor family.
    Contains 6 ANK repeats.
  • 翻译后修饰
    Phosphorylated by RPS6KA1; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation.
  • 细胞定位
    Cytoplasm. Nucleus.
  • Information by UniProt

文献

ab7548 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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