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功能
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
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疾病相关
Ectodermal dysplasia, anhidrotic, with T-cell immunodeficiency autosomal dominant
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序列相似性
Belongs to the NF-kappa-B inhibitor family.
Contains 5 ANK repeats.
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翻译后修饰
Phosphorylated; disables inhibition of NF-kappa-B DNA-binding activity. Phosphorylation at positions 32 and 36 is prerequisite to recognition by UBE2D3 leading to polyubiquitination and subsequent degradation.
Sumoylated; sumoylation requires the presence of the nuclear import signal. Sumoylation blocks ubiquitination and proteasome-mediated degradation of the protein thereby increasing the protein stability.
Monoubiquitinated at Lys-21 and/or Lys-22 by UBE2D3. Ubiquitin chain elongation is then performed by CDC34 in cooperation with the SCF(FBXW11) E3 ligase complex, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. The resulting polyubiquitination leads to protein degradation. Also ubiquitinated by SCF(BTRC) following stimulus-dependent phosphorylation at Ser-32 and Ser-36.
Deubiquitinated by porcine reproductive and respiratory syndrome virus Nsp2 protein, which thereby interferes with NFKBIA degradation and impairs subsequent NF-kappa-B activation.
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细胞定位
Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export.
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Information by UniProt
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数据库链接
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别名
- I kappa B alpha antibody
- I-kappa-B-alpha antibody
- IkappaBalpha antibody
- IkB-alpha antibody
- IKBA antibody
- IKBA_HUMAN antibody
- IKBalpha antibody
- MAD 3 antibody
- MAD3 antibody
- Major histocompatibility complex enhancer-binding protein MAD3 antibody
- NF kappa B inhibitor alpha antibody
- NF-kappa-B inhibitor alpha antibody
- NFKBI antibody
- NFKBIA antibody
- Nuclear factor of kappa light chain gene enhancer in B cells antibody
- Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor alpha antibody
see all