概述

  • 产品名称Anti-Ihh抗体
    参阅全部 Ihh 一抗
  • 描述
    兔多克隆抗体to Ihh
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    KLH conjugated synthetic peptide designed between amino acids 50-80 from the N-terminal region of Human IHH (NP_002172.2).

  • 阳性对照
    • HepG2 cell lysate

性能

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应用

Our Abpromise guarantee covers the use of ab124122 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 45 kDa.

靶标

  • 功能Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP).
  • 组织特异性Expressed in embryonic lung, and in adult kidney and liver.
  • 疾病相关Defects in IHH are the cause of brachydactyly type A1 (BDA1) [MIM:112500]. BDA1 is an autosomal dominant disorder characterized by middle phalanges of all the digits rudimentary or fused with the terminal phalanges. The proximal phalanges of the thumbs and big toes are short.
    Defects in IHH are a cause of acrocapitofemoral dysplasia (ACFD) [MIM:607778]. ACFD is a disorder characterized by short stature of variable severity with postnatal onset. The most constant radiographic abnormalities are observed in the tubular bones of the hands and in the proximal part of the femur. Cone-shaped epiphyses or a similar epiphyseal configuration with premature epimetaphyseal fusion result in shortening of the skeletal components involved. Cone-shaped epiphyses were also present to a variable extent at the shoulders, knees, and ankles.
  • 序列相似性Belongs to the hedgehog family.
  • 翻译后修饰The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity. Both activities result in the cleavage of the full-length protein and covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-terminal fragment (N-product). The N-product is the active species in both local and long-range signaling, whereas the C-product has no signaling activity.
    Cholesterylation is required for N-product targeting to lipid rafts and multimerization.
    Palmitoylated. N-palmitoylation is required for N-product multimerization and full activity.
  • 细胞定位Secreted > extracellular space. The C-terminal peptide diffuses from the cell and Cell membrane. The N-terminal peptide remains associated with the cell surface.
  • Information by UniProt
  • 数据库链接
  • 别名
    • BDA1 antibody
    • HHG-2 antibody
    • HHG2 antibody
    • IHH antibody
    • IHH_HUMAN antibody
    • Indian Hedgehog antibody
    • Indian hedgehog homolog antibody
    • Indian hedgehog protein antibody
    • Indian hedgehog protein C-product antibody
    • Indian hedgehog protein N-product antibody
    see all

Anti-Ihh antibody 图像

  • Anti-Ihh antibody (ab124122) at 1/100 dilution + HepG2 cell line lysates at 35 µg

    Predicted band size : 45 kDa

Anti-Ihh antibody (ab124122)参考文献

ab124122 has not yet been referenced specifically in any publications.

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