Anti-IgM抗体[KT16] (ab110653)
Key features and details
- Mouse monoclonal [KT16] to IgM
- Suitable for: Sandwich ELISA
- Reacts with: Human
- Isotype: IgG1
概述
-
产品名称
Anti-IgM抗体[KT16]
参阅全部 IgM 一抗 -
描述
小鼠单克隆抗体[KT16] to IgM -
宿主
Mouse -
特异性
ab110653 does not cross-react with Human IgG and recombinant Human IgG1, IgG2, IgG3, IgG4, IgA and IgE. -
经测试应用
适用于: Sandwich ELISAmore details -
种属反应性
与反应: Human -
免疫原
Recombinant Human IgM
-
阳性对照
- Human serum
-
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
Preservative: 0.1% Sodium azide
Constituent: PBS -
Concentration information loading...
-
纯度
Protein A purified -
克隆
单克隆 -
克隆编号
KT16 -
同种型
IgG1 -
研究领域
相关产品
-
Recombinant Protein
-
sELISA pair antibody
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab110653于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
Sandwich ELISA |
Use a concentration of 5 µg/ml. Can be paired for Sandwich ELISA with HRP Mouse monoclonal [KT38] to IgM (ab106742). Use ab106742 as the dection antibody and ab110653 as the capture antibody.
|
说明 |
---|
Sandwich ELISA
Use a concentration of 5 µg/ml. Can be paired for Sandwich ELISA with HRP Mouse monoclonal [KT38] to IgM (ab106742). Use ab106742 as the dection antibody and ab110653 as the capture antibody. |
靶标
-
相关性
IgM normally constitutes about 10% of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and predominates in certain antibody responses such as 'natural' blood group antibodies. IgM (with IgD) is the major immunoglobulin expressed on the surface of B cells. The gene for the mu constant region contains four domains separated by short intervening sequences. Class specific anti immunoglobulin antibodies are useful for: The characterization of malignant B cell proliferations. All but acute lymphocytic leukemias share either surface or intra cytoplasmic Ig with an isotypic restriction, which suggest the monoclonal nature of the cell population. Most of the chronic lymphocytic leukemias, non Hodgkin lymphomas and Burkitt's lymphoma bear surface IgM, whereas plasmocytes from Waldenström's disease bear intracytoplasmic IgM. The other isotypes are less frequently found. On the other hand multiple myelomas are usually of the IgG or IgA type. Characterization of plasma cells in inflammatory conditions: Plasma cell typing can be of use for the classification of intestinal inflammatory conditions such as inflammatory bowel disease and allergic conditions. In the latter a specific increase in the number of IgE plasma cells can be demonstrated. -
细胞定位
Isoform 1: Secreted. During differentiation, B lymphocytes switch from expression of membrane bound IgM to secretion of IgM. Isoform 2: Cell membrane; Single pass type I membrane protein. -
数据库链接
- Entrez Gene: 3507 Human
- Omim: 147020 Human
- SwissProt: P01871 Human
-
别名
- AGM1 antibody
- Constant region of heavy chain of IgM antibody
- DKFZp686I15196 antibody
see all
图片
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
-
SDS download
-
Datasheet download
文献 (0)
ab110653 尚未被引用在任何文献中。