概述

  • 产品名称Anti-IGFBP5抗体[1.A.18]
    参阅全部 IGFBP5 一抗
  • 描述
    小鼠单克隆抗体[1.A.18] to IGFBP5
  • 特异性Strongly recognizes human IGFBP 5 on ELISA and Western blot analysis. It is not cross reactive to other IGF binding proteins in Western blot analysis (1/100 dilution).
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Human recombinant IGF binding Protein 5 (yeast derived recombinant protein).

  • 阳性对照

性能

应用

Our Abpromise guarantee covers the use of ab4257 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/100 - 1/1000.
WB 1/100 - 1/1000. Predicted molecular weight: 30 kDa.

靶标

  • 功能IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
  • 组织特异性Osteosarcoma, and at lower levels in liver, kidney and brain.
  • 序列相似性Contains 1 IGFBP N-terminal domain.
    Contains 1 thyroglobulin type-1 domain.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • IBP 5 antibody
    • IBP-5 antibody
    • IBP5 antibody
    • IBP5_HUMAN antibody
    • IGF binding protein 5 antibody
    • IGF BP5 antibody
    • IGF-binding protein 5 antibody
    • IGFBP 5 antibody
    • IGFBP-5 antibody
    • IGFBP5 antibody
    • Insulin like growth factor binding protein 5 antibody
    • Insulin-like growth factor-binding protein 5 antibody
    see all

Anti-IGFBP5 antibody [1.A.18] (ab4257)参考文献

This product has been referenced in:
  • Greenall SA  et al. Biochemical characterization of individual human glycosylated pro-insulin-like growth factor (IGF)-II and big-IGF-II isoforms associated with cancer. J Biol Chem 288:59-68 (2013). Read more (PubMed: 23166326) »
  • Sokolovic A  et al. Insulin-like growth factor binding protein 5 enhances survival of LX2 human hepatic stellate cells. Fibrogenesis Tissue Repair 3:3 (2010). WB ; Human . Read more (PubMed: 20163708) »

See all 3 Publications for this product

Product Wall

Thank you for your enquiry. This antibody was tested in Indirect ELISA using the immunogen human recombinant IGF-binding Protein 5. The immunogen was coated on microtiter plates, blocked and stained with ab4257 at a dilution of 1:50. We do not have...

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Thank you very much for your patience, I have only just heard back from the antibody's originator. The molecular weight is 23 kDa (252 amino acids) according to a reference which describes all 8 ILGFBP isoforms. J. Kostecka, J. Blahovec. Endocrine ...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"