Anti-IGFBP3抗体- N-terminal (ab75988)

概述

  • 产品名称
    Anti-IGFBP3抗体- N-terminal
    参阅全部 IGFBP3 一抗
  • 描述
    兔多克隆抗体to IGFBP3 - N-terminal
  • 经测试应用
    适用于: WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Rat, Human
    预测可用于: Mouse
  • 免疫原

    KLH-conjugated synthetic peptide selected from the N-terminal region of Rat IGFBP3

  • 阳性对照
    • WB: HepG2 cell line lysate; IHC: Human hepatocarcinoma tissue .

性能

应用

Our Abpromise guarantee covers the use of ab75988 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/50 - 1/100. Predicted molecular weight: 32 kDa.
ELISA 1/1000.
IHC-P 1/10 - 1/50.

靶标

  • 功能
    IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
  • 组织特异性
    Expressed by most tissues. Present in plasma.
  • 序列相似性
    Contains 1 IGFBP N-terminal domain.
    Contains 1 thyroglobulin type-1 domain.
  • 发展阶段
    IGFBP3 levels are higher during extrauterine life and peak during puberty.
  • 结构域
    The thyroglobulin type-1 domain mediates interaction with HN.
  • 翻译后修饰
    Phosphorylation sites are present in the extracelllular medium.
  • 细胞定位
    Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Acid stable subunit of the 140 K IGF complex antibody
    • Binding protein 29 antibody
    • Binding protein 53 antibody
    • BP 53 antibody
    • BP53 antibody
    • Growth hormone dependent binding protein antibody
    • IBP 3 antibody
    • IBP-3 antibody
    • IBP3 antibody
    • IBP3_HUMAN antibody
    • IGF binding protein 3 antibody
    • IGF-binding protein 3 antibody
    • IGFBP 3 antibody
    • IGFBP-3 antibody
    • IGFBP3 antibody
    • Insulin Like Growth Factor Binding Protein 3 antibody
    • Insulin-like growth factor binding protein 3 precursor antibody
    • Insulin-like growth factor-binding protein 3 antibody
    see all

图片

  • Anti-IGFBP3 antibody - N-terminal (ab75988) at 1/60 dilution + HepG2 cell line lysates at 35 µg

    Predicted band size : 32 kDa
    Observed band size : 32 kDa
    Additional bands at : 46 kDa. We are unsure as to the identity of these extra bands.
  • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded human hepatocarcinoma tissue with 1/10-1/50 ab75988, used in conjunction with a peroxidase-conjugated secondary antibody, followed by DAB staining.

文献

ab75988 has not yet been referenced specifically in any publications.

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