概述

  • 产品名称Anti-IGFBP2抗体[EPR3380(2)]
    参阅全部 IGFBP2 一抗
  • 描述
    兔单克隆抗体[EPR3380(2)] to IGFBP2
  • 经测试应用适用于: WB, IHC-Pmore details
    不适用于: Flow Cyt,ICC or IP
  • 种属反应性
    与反应: Human
  • 免疫原

    A synthetic peptide corresponding to residues at the C-terminus of Human IGFBP2.

  • 阳性对照
    • Human kidney tissue, Human endometrial adenocarcinoma tissue. T47-D, SH-SY5Y, BxPC-3, A549 and NCCIT cell lysates.
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

性能

应用

Our Abpromise guarantee covers the use of ab109284 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/10000 - 1/50000. Predicted molecular weight: 35 kDa.
IHC-P 1/100 - 1/250. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
  • 应用说明Is unsuitable for Flow Cyt,ICC or IP.
  • 靶标

    • 功能Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
    • 序列相似性Contains 1 IGFBP N-terminal domain.
      Contains 1 thyroglobulin type-1 domain.
    • 结构域The C-terminus is required for IGF-binding and growth inhibition.
    • 翻译后修饰O-glycosylated.
    • 细胞定位Secreted.
    • Information by UniProt
    • 数据库链接
    • 别名
      • BP 2 antibody
      • BP2 antibody
      • IBP 2 antibody
      • IBP-2 antibody
      • IBP2 antibody
      • IBP2_HUMAN antibody
      • IGF binding protein 2 antibody
      • IGF BP53 antibody
      • IGF-binding protein 2 antibody
      • IGFBP 2 antibody
      • IGFBP-2 antibody
      • IGFBP2 antibody
      • IGFBP53 antibody
      • Insulin like growth factor binding protein 2 36kDa antibody
      • Insulin like growth factor binding protein 2 antibody
      • Insulin like growth factor-binding protein 2 precursor antibody
      • Insulin-like growth factor-binding protein 2 antibody
      see all

    Anti-IGFBP2 antibody [EPR3380(2)] 图像

    • All lanes : Anti-IGFBP2 antibody [EPR3380(2)] (ab109284) at 1/10000 dilution

      Lane 1 : T47-D cell lysate
      Lane 2 : SH-SY5Y cell lysate
      Lane 3 : BxPC-3 cell lysate
      Lane 4 : A549 cell lysate
      Lane 5 : NCCIT cell lysate

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 35 kDa
    • Immunohistochemical analysis of paraffin-embedded kidney tissue using 1/100 ab109284.
    • Immunohistochemical analysis of paraffin-embedded endometrial adenocarcinoma tissue with ab109284 at 1/100 dilution.

    Anti-IGFBP2 antibody [EPR3380(2)] (ab109284)参考文献

    This product has been referenced in:
    • Wang C  et al. Human adipocytes stimulate invasion of breast cancer MCF-7 cells by secreting IGFBP-2. PLoS One 10:e0119348 (2015). WB ; Human . Read more (PubMed: 25747684) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"