Anti-IGFBP2抗体[1.A.16] (ab4243)

概述

  • 产品名称Anti-IGFBP2抗体[1.A.16]
    参阅全部 IGFBP2 一抗
  • 描述
    小鼠单克隆抗体[1.A.16] to IGFBP2
  • 特异性Recognizes human IGFBP 2 on ELISA analysis.
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Yeast derived recombinant protein (Human).

性能

应用

Our Abpromise guarantee covers the use of ab4243 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent dilution.
WB Use at an assay dependent dilution. Predicted molecular weight: 35 kDa.

靶标

  • 功能Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
  • 序列相似性Contains 1 IGFBP N-terminal domain.
    Contains 1 thyroglobulin type-1 domain.
  • 结构域The C-terminus is required for IGF-binding and growth inhibition.
  • 翻译后修饰O-glycosylated.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • BP 2 antibody
    • BP2 antibody
    • IBP 2 antibody
    • IBP-2 antibody
    • IBP2 antibody
    • IBP2_HUMAN antibody
    • IGF binding protein 2 antibody
    • IGF BP53 antibody
    • IGF-binding protein 2 antibody
    • IGFBP 2 antibody
    • IGFBP-2 antibody
    • IGFBP2 antibody
    • IGFBP53 antibody
    • Insulin like growth factor binding protein 2 36kDa antibody
    • Insulin like growth factor binding protein 2 antibody
    • Insulin like growth factor-binding protein 2 precursor antibody
    • Insulin-like growth factor-binding protein 2 antibody
    see all

Anti-IGFBP2 antibody [1.A.16] (ab4243)参考文献

This product has been referenced in:
  • Wang C  et al. Human adipocytes stimulate invasion of breast cancer MCF-7 cells by secreting IGFBP-2. PLoS One 10:e0119348 (2015). WB ; Human . Read more (PubMed: 25747684) »
  • Walker G  et al. Insulin-like growth factor binding proteins IGFBP3, IGFBP4, and IGFBP5 predict endocrine responsiveness in patients with ovarian cancer. Clin Cancer Res 13:1438-44 (2007). Read more (PubMed: 17332286) »

See all 2 Publications for this product

Product Wall

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Western blot
Sample Human Cell lysate - whole cell (glioma cell-line U87MG)
Loading amount 50 µg
Specification glioma cell-line U87MG
Gel Running Conditions Reduced Denaturing
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 23°C
Username

Mr. Paul Eve

Verified customer

提交于 Jan 21 2008

Thank you for your patience. Concerning ab4243, Insulin-Like Growth Factor Binding Protein 2 (IGFBP2), the positive controls are: T98G cell lysate, MES-SA/Dx5 cell lysate, or human placenta. Please let me know if I can be of further assistance.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"