概述

  • 产品名称Anti-IGF2BP2抗体
    参阅全部 IGF2BP2 一抗
  • 描述
    兔多克隆抗体to IGF2BP2
  • 经测试应用适用于: WB, IPmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rabbit, Horse, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla
  • 免疫原

    Synthetic peptide, corresponding to a region within amino acids 549-599 of Human IGF2BP2 using the numbering given in entry NP_006539.3.

  • 阳性对照
    • Whole cell lysate from 293T, Jurkat and HeLa cells.

性能

应用

Our Abpromise guarantee covers the use of ab117809 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/2000 - 1/10000. Predicted molecular weight: 66 kDa.
IP Use at 2-10 µg/mg of lysate.

靶标

  • 功能Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. May regulate translation of target mRNAs.
  • 组织特异性Expressed in oocytes, granulosa cells of small and growing follicles, Leydig cells, spermatogonia and semen (at protein level). Expressed in testicular cancer (at protein level). Expressed weakly in heart, placenta, skeletal muscle, bone marrow, colon, kidney, salivary glands, testis and pancreas. Detected in fetal liver, fetal ovary, gonocytes and interstitial cells of the testis.
  • 序列相似性Belongs to the RRM IMP/VICKZ family.
    Contains 4 KH domains.
    Contains 2 RRM (RNA recognition motif) domains.
  • 结构域The third and fourth KH domains are important for binding to the untranslated region (UTR) of target mRNA.
  • 细胞定位Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Localizes at the connecting piece and the tail of the spermatozoa.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Hepatocellular carcinoma autoantigen p62 antibody
    • IF2B2_HUMAN antibody
    • IGF 2 mRNA binding protein 2 antibody
    • IGF II mRNA binding protein 2 antibody
    • IGF-II mRNA-binding protein 2 antibody
    • IGF2 mRNA-binding protein 2 antibody
    • Igf2bp2 antibody
    • IMP 2 antibody
    • IMP-2 antibody
    • IMP2 antibody
    • Insulin like growth factor 2 mRNA binding protein 2 antibody
    • Insulin-like growth factor 2 mRNA-binding protein 2 antibody
    • OTTHUMP00000082606 antibody
    • OTTHUMP00000082607 antibody
    • OTTHUMP00000082608 antibody
    • p62 antibody
    • VICKZ 2 antibody
    • VICKZ family member 2 antibody
    • VICKZ2 antibody
    see all

Anti-IGF2BP2 antibody 图像

  • All lanes : Anti-IGF2BP2 antibody (ab117809) at 0.1 µg/ml

    Lane 1 : Whole cell lysate from 293T cells at 50 µg
    Lane 2 : Whole cell lysate from 293T cells at 15 µg
    Lane 3 : Whole cell lysate from Jurkat cells at 50 µg
    Lane 4 : Whole cell lysate from HeLa cells at 50 µg

    Developed using the ECL technique

    Predicted band size : 66 kDa


    Exposure time : 3 minutes
  • ab117809 at 1 µg/ml staining IGF2BP2 by WB, following immunoprecipitation of whole cell lysate from 293T cells.
    Lane 1; IP using an antibody to an upstream epitope.
    Lane 2; IP using ab117809 at 6 µg/mg lysate.
    Lane 3; IP using control IgG.
    1 mg of lysate was used for IP and 20% of IP was loaded. Detection utilised ECL with a 30 second exposure.

Anti-IGF2BP2 antibody (ab117809)参考文献

ab117809 has not yet been referenced specifically in any publications.

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