Anti-IGF2抗体(Biotin) (ab83142)

概述

• 产品名称
  Anti-IGF2抗体(Biotin)
  参阅全部 IGF2 一抗
• 描述
  兔多克隆抗体to IGF2 (Biotin)
• 偶联物
  Biotin
• 经测试应用
  适用于: ELISA, Sandwich ELISA, WBmore details
• 种属反应性
  与反应: Human
  
• 免疫原

  Highly pure (>98%) recombinant Human IGF2.

性能

• 形式
  Lyophilised:Reconstitute in sterile PBS containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml.
• 存放说明
  Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• 存储溶液
  Preservative: None
  Constituents: PBS, pH 7.2
• Concentration information loading...
• 纯度
  Protein A purified
• 纯化说明
  ab83142 was purified by affinity chromatography and then biotinylated.
• 克隆
  多克隆
• 同种型
  IgG
• 研究领域
  • Signal Transduction
  • Growth Factors/Hormones
  • Insulin / Insulin-like

  • Cancer
  • Growth factors
  • Insulin and insulin-like

  • Developmental Biology
  • Post embryonic development
  • Growth hormones

相关产品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• sELISA pair antibody
  • Anti-IGF2 antibody (ab109789)

应用

靶标

• 功能
  The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.
  Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
• 疾病相关
  Epigenetic changes of DNA hypomethylation in IGF2 are a cause of Silver-Russell syndrome (SIRS) [MIM:180860]. SIRS is a clinically heterogeneous condition characterized by severe intrauterine growth retardation, poor postnatal growth, craniofacial features such as a triangular shaped face and a broad forehead, body asymmetry, and a variety of minor malformations.
• 序列相似性
  Belongs to the insulin family.
• 翻译后修饰
  O-glycosylated with a core 1 or possibly core 8 glycan.
• 细胞定位
  Secreted.

• Target information above from: UniProt accession P01344 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 3481 Human
  • Omim: 147470 Human
  • SwissProt: P01344 Human
  • Unigene: 272259 Human
  • Unigene: 718427 Human
• 别名
  • C11orf43 antibody
  • IGF 2 antibody
  • IGF II antibody

  • IGF-II antibody
  • IGF2 antibody
  • IGF2_HUMAN antibody
  • IGFII antibody
  • INSIGF antibody
  • insulin like growth factor 2 (somatomedin A) antibody
  • Insulin like Growth Factor 2 antibody
  • Insulin like growth factor II antibody
  • Insulin like growth factor II precursor antibody
  • Insulin like growth factor type 2 antibody
  • pp9974 antibody
  • Preptin antibody
  • putative insulin like growth factor II associated protein antibody
  • Somatomedin A antibody
  • Somatomedin-A antibody

  see all

实验方案

• Western blot protocols