概述
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产品名称Anti-IGF2抗体(Biotin)
参阅全部 IGF2 一抗 -
描述兔多克隆抗体to IGF2 (Biotin)
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宿主Rabbit
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偶联物Biotin
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经测试应用适用于: Sandwich ELISA, WBmore details
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种属反应性与反应: Human
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免疫原
Highly pure (>98%) recombinant Human IGF2.
性能
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形式Lyophilised:Reconstitute in sterile PBS containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml.
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存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
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存储溶液Preservative: None
Constituents: PBS, pH 7.2 -
Concentration information loading... -
纯度Protein A purified
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纯化说明ab83142 was purified by affinity chromatography and then biotinylated.
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克隆多克隆
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同种型IgG
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研究领域
相关产品
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Compatible Secondaries
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sELISA pair antibody
应用
Our Abpromise guarantee covers the use of ab83142 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Sandwich ELISA | Use a concentration of 0.25 - 1 µg/ml. Can be paired for Sandwich ELISA with Rabbit polyclonal to IGF2 (ab109789). | |
| WB | Use a concentration of 0.1 - 0.2 µg/ml. Predicted molecular weight: 20 kDa. |
靶标
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功能The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.
Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3. -
疾病相关Epigenetic changes of DNA hypomethylation in IGF2 are a cause of Silver-Russell syndrome (SIRS) [MIM:180860]. SIRS is a clinically heterogeneous condition characterized by severe intrauterine growth retardation, poor postnatal growth, craniofacial features such as a triangular shaped face and a broad forehead, body asymmetry, and a variety of minor malformations.
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序列相似性Belongs to the insulin family.
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翻译后修饰O-glycosylated with a core 1 or possibly core 8 glycan.
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细胞定位Secreted.
- Information by UniProt
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数据库链接
- Entrez Gene: 3481 Human
- Omim: 147470 Human
- SwissProt: P01344 Human
- Unigene: 272259 Human
- Unigene: 718427 Human
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别名
- C11orf43 antibody
- IGF 2 antibody
- IGF II antibody
see all
文献
ab83142 has not yet been referenced specifically in any publications.
客户评价及客户问答
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"