- 数据表
- 具体的参考文献 (2)
- 实验方案
概述
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产品名称Anti-IGF1抗体
参阅全部 IGF1 一抗 -
描述兔多克隆抗体to IGF1
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经测试应用适用于: WB, Neutralisingmore details
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种属反应性与反应: Mouse, Recombinant fragment
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免疫原
Recombinant murine IGF1
性能
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形式Liquid
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存放说明Shipped at 4°C. Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
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存储溶液Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 30% Glycerol, 0.5% BSA, PBS, pH 7.2 -
Concentration information loading... -
纯度Immunogen affinity purified
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克隆多克隆
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同种型IgG
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研究领域
相关产品
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Compatible Secondaries
应用
Our Abpromise guarantee covers the use of ab63926 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | Use a concentration of 0.5 - 4 µg/ml. Detects a band of approximately 9 kDa (predicted molecular weight: 17 kDa). | |
| Neutralising | Use a concentration of 2 - 4 µg/ml. |
靶标
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功能The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.
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疾病相关Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
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序列相似性Belongs to the insulin family.
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细胞定位Secreted.
- Information by UniProt
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数据库链接
- Entrez Gene: 16000 Mouse
- SwissProt: P05017 Mouse
- Unigene: 268521 Mouse
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形式There are 2 isoforms produced by alternative splicing. Isoform 1 also known as: IGF-IB; Isoform 2 also known as: IGF-IA.
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别名
- IBP1 antibody
- IGF I antibody
- IGF IA antibody
see all
Anti-IGF1 antibody 图像
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Western blot - IGF1 antibody (ab63926)All lanes : Anti-IGF1 antibody (ab63926) at 4 µg/ml
Lane 1 : Recombinant murine IGF1 at 0.25 µg
Lane 2 : Recombinant murine IGF1 at 1 µg
Predicted band size : 17 kDa
Observed band size : 9 kDa (why is the actual band size different from the predicted?)
Anti-IGF1 antibody (ab63926)参考文献
This product has been referenced in:
- Garcia LA et al. 1,25(OH)2vitamin D3 stimulates myogenic differentiation by inhibiting cell proliferation and modulating the expression of promyogenic growth factors and myostatin in C2C12 skeletal muscle cells. Endocrinology 152:2976-86 (2011). WB ; Mouse . Read more (PubMed: 21673099) »
- Mair M et al. Signal transducer and activator of transcription 3 protects from liver injury and fibrosis in a mouse model of sclerosing cholangitis. Gastroenterology 138:2499-508 (2010). WB . Read more (PubMed: 20193684) »
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"