Anti-IgA抗体, prediluted (ab75671)

概述

  • 产品名称Anti-IgA抗体, prediluted
    参阅全部 IgA 一抗
  • 描述
    兔多克隆抗体to IgA, prediluted
  • 特异性This antibody recognizes a protein of 50kDa, identified as alpha heavy chain of human immunoglobulins. It reacts with both IgA1 and IgA2 isotypes. It does not cross-react with gamma (IgG), mu (IgM), epsilon (IgE), or delta (IgD), heavy chains, T-cells, monocytes, granulocytes, or erythrocytes.
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length IgA isolated from a pool of normal human sera.

  • 阳性对照
    • Human Tonsil tissue.
  • 常规说明


    This antibody is useful in the identification of leukemias, plasmacytomas and certain non-Hodgkin’s lymphomas.

性能

  • 形式Prediluted
  • 存放说明Shipped at 4°C. Store at +4°C.
  • 存储溶液Preservative: 15mM Sodium Azide
    Constituents: 0.5 mol/L Tris HCl, pH 7.6, and a stabilizing protein.
  • Concentration information loading...
  • 纯度Protein A purified
  • Primary antibody说明This antibody is useful in the identification of leukemias, plasmacytomas and certain non-Hodgkin’s lymphomas.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab75671 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/1. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Ready to use.

靶标

  • 相关性Human IgA (immunoglobulin A) is a glycosylated protein of 160 kDa and is produced as a monomer or as a J chain linked dimer. Monomeric IgA constitutes 5-15 % of the serum immunoglobulins whereas dimeric IgA is localized to mucosa surfaces such as saliva, gastrointestinal secretion, bronchial fluids and milk. Mucosal IgA plays a major role in host defence by neutralising infectious agents at mucosal surfaces. The production is usually local and antigen specific IgA producing B cells can be found in regions under the lamina propria where they mature into dimeric IgA producing plasma cells. IgA deficiency is the most common immunodeficiency that may affect both serum and mucosal produced IgA. OR: The secretory component is a component of immunoglobulin A (IgA) which consists of a portion of the polymeric immunoglobulin receptor. Polymeric IgA binds to the polymeric immunoglobulin receptor on the basolateral surface of epithelial cells and is taken up into the cell via transcytosis. The receptor-IgA complex passes through the cellular compartments before being secreted on the luminal surface of the epithelial cells, still attached to the receptor. Proteolysis of the receptor occurs and the dimeric IgA molecule, along with the secretory component, are free to diffuse throughout the lumen.
  • 细胞定位Secreted
  • 数据库链接
  • 别名
    • Hepatocellular carcinoma-associated protein TB6 antibody
    • Ig alpha 1 chain C region antibody
    • Ig alpha 2 chain C region antibody
    • IGHA antibody
    • IGHA1 antibody
    • IGHA2 antibody
    • Immunoglobulin heavy constant alpha 1 antibody
    • Immunoglobulin heavy constant alpha 2 A2m marker antibody
    • Immunoglobulin heavy constant alpha 2 antibody
    • PIgR antibody
    • Poly-Ig receptor antibody
    • polymeric immunoglobulin receptor antibody
    • polymeric immunoglobulin receptor Secretory component antibody
    see all

Anti-IgA antibody, prediluted 图像

  • Formalin-fixed, paraffin-embedded human tonsil stained with ab75671, using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of IgA-secreting cells.

Anti-IgA antibody, prediluted (ab75671)参考文献

ab75671 has not yet been referenced specifically in any publications.

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