Anti-IgA抗体[IgA5-3B] (Biotin) (ab53270)

概述

  • 产品名称Anti-IgA抗体[IgA5-3B] (Biotin)
    参阅全部 IgA 一抗
  • 描述
    小鼠单克隆抗体[IgA5-3B] to IgA (Biotin)
  • 偶联物Biotin
  • 特异性ab53270 recognises IgA. It does not cross-react with IgG or IgM; it has been shown to detect secreted IgA in cat saliva and rhesus monkey jejunal washes
  • 经测试应用适用于: ELISAmore details
  • 种属反应性
    与反应: Cat, Dog, Human, Rhesus monkey, Marmoset (common)
  • 免疫原

    Purified monkey IgA, from serum.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: 0.05% Sodium Azide
    Constituents: PBS, pH 7.2
  • Concentration information loading...
  • 纯度Protein A purified
  • 纯化说明ab53270 is prepared by affinity chromatography on Protein A from tissue culture supernatant.
  • 克隆单克隆
  • 克隆编号IgA5-3B
  • 同种型IgG1
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab53270 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA
  • 应用说明ELISA: Use at an assay dependent dilution. 1 - 10 ug/ml is a good starting point for ELISA.



    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 相关性Human IgA (immunoglobulin A) is a glycosylated protein of 160 kDa and is produced as a monomer or as a J chain linked dimer. Monomeric IgA constitutes 5-15 % of the serum immunoglobulins whereas dimeric IgA is localized to mucosa surfaces such as saliva, gastrointestinal secretion, bronchial fluids and milk. Mucosal IgA plays a major role in host defence by neutralising infectious agents at mucosal surfaces. The production is usually local and antigen specific IgA producing B cells can be found in regions under the lamina propria where they mature into dimeric IgA producing plasma cells. IgA deficiency is the most common immunodeficiency that may affect both serum and mucosal produced IgA. OR: The secretory component is a component of immunoglobulin A (IgA) which consists of a portion of the polymeric immunoglobulin receptor. Polymeric IgA binds to the polymeric immunoglobulin receptor on the basolateral surface of epithelial cells and is taken up into the cell via transcytosis. The receptor-IgA complex passes through the cellular compartments before being secreted on the luminal surface of the epithelial cells, still attached to the receptor. Proteolysis of the receptor occurs and the dimeric IgA molecule, along with the secretory component, are free to diffuse throughout the lumen.
    • 细胞定位Secreted
    • 数据库链接
    • 别名
      • Hepatocellular carcinoma-associated protein TB6 antibody
      • Ig alpha 1 chain C region antibody
      • Ig alpha 2 chain C region antibody
      • IGHA antibody
      • IGHA1 antibody
      • IGHA2 antibody
      • Immunoglobulin heavy constant alpha 1 antibody
      • Immunoglobulin heavy constant alpha 2 A2m marker antibody
      • Immunoglobulin heavy constant alpha 2 antibody
      • PIgR antibody
      • Poly-Ig receptor antibody
      • polymeric immunoglobulin receptor antibody
      • polymeric immunoglobulin receptor Secretory component antibody
      see all

    Anti-IgA antibody [IgA5-3B] (Biotin) (ab53270)参考文献

    ab53270 has not yet been referenced specifically in any publications.

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