概述

  • 产品名称Anti-IFT122抗体
  • 描述
    兔多克隆抗体to IFT122
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment, corresponding to a region within amino acids 667-883 of Human IFT122 (AAH03045).

  • 阳性对照
    • 293T whole cell lysate; Hepatoma tissue.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 20% Glycerol, 0.75% Glycine, 1.21% Tris
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明ab111838 is purified by antigen-affinity chromatography.
  • 克隆多克隆
  • 同种型IgG

应用

Our Abpromise guarantee covers the use of ab111838 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 129 kDa.
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. or Tris-EDTA buffer (pH 8.0)

靶标

  • 功能Required for cilia formation and Shh signaling during neuronal patterning.
  • 组织特异性Expressed in many tissues. Predominant expression in testis and pituitary.
  • 疾病相关Defects in IFT122 are a cause of cranioectodermal dysplasia type 1 (CED1) [MIM:218330]. CED1 is a disorder characterized by craniofacial, skeletal and ectodermal abnormalities. Clinical features include dolichocephaly (with or without sagittal suture synostosis), scaphocephaly, short stature, limb shortening, short ribs, narrow chest, brachydactyly, renal failure and hepatic fibrosis, small and abnormally shaped teeth, sparse hair, skin laxity and abnormal nails.
  • 序列相似性Contains 7 WD repeats.
  • 细胞定位Cytoplasm. Cell projection > cilium. Cytoplasm > cytoskeleton > cilium basal body. Localizes to photoreceptor connecting cilia.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CED antibody
    • IF122_HUMAN antibody
    • IFT122 antibody
    • Intraflagellar transport 122 homolog (Chlamydomonas) antibody
    • Intraflagellar transport protein 122 homolog antibody
    • SPG antibody
    • WD repeat domain 10 antibody
    • WD repeat-containing protein 10 antibody
    • WD repeat-containing protein 140 antibody
    • WDR10 antibody
    • WDR10p antibody
    • WDR140 antibody
    see all

Anti-IFT122 antibody 图像

  • Anti-IFT122 antibody (ab111838) at 1/1000 dilution + 293T cell line lysate at 30 µg

    Predicted band size : 129 kDa
  • ab111838, at 1/500 dilution, staining IFT122 in Formalin-fixed, Paraffin-embedded Hepatoma tissue by Immunohistochemistry.

Anti-IFT122 antibody (ab111838)参考文献

ab111838 has not yet been referenced specifically in any publications.

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