Anti-IFNGR1 (phospho Y457)抗体(ab61062)

概述

  • 产品名称Anti-IFNGR1 (phospho Y457)抗体
    参阅全部 IFNGR1 一抗
  • 描述
    兔多克隆抗体to IFNGR1 (phospho Y457)
  • 特异性ab61062 detects endogenous levels of IFNGR1 only when phosphorylated at tyrosine 457.
  • 经测试应用适用于: WB, IHC-P, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Synthetic phosphopeptide derived from human IFNGR1 around the phosphorylation site of tyrosine 457 (GYpDKP).

  • 阳性对照
    • Human brain tissue, COS7 cell extract.

性能

应用

Our Abpromise guarantee covers the use of ab61062 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 80 kDa (predicted molecular weight: 54 kDa).
IHC-P 1/50 - 1/100.
ELISA 1/20000.

靶标

  • 功能Receptor for interferon gamma. Two receptors bind one interferon gamma dimer.
  • 疾病相关Defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]; also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.
  • 序列相似性Belongs to the type II cytokine receptor family.
    Contains 2 fibronectin type-III domains.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • 翻译后修饰Phosphorylated at Ser/Thr residues.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Antiviral Protein Type II antibody
    • Antiviral protein, type 2 antibody
    • AVP type II antibody
    • AVP, type 2 antibody
    • CD 119 antibody
    • CD119 antibody
    • CD119 antigen antibody
    • CDw119 antibody
    • FLJ45734 antibody
    • IFN gamma R alpha antibody
    • IFN gamma R antibody
    • IFN gamma R1 antibody
    • IFN-gamma receptor 1 antibody
    • IFN-gamma-R1 antibody
    • IFNG R1 antibody
    • IFNGR 1 antibody
    • IFNGR antibody
    • IFNGR1 antibody
    • Immune interferon receptor 1 antibody
    • Immune interferon receptor for antibody
    • INGR1_HUMAN antibody
    • Interferon gamma receptor 1 antibody
    • Interferon gamma receptor alpha chain antibody
    • Interferon gamma receptor alpha chain precursor antibody
    see all

Anti-IFNGR1 (phospho Y457) antibody 图像

  • Immunohistochemistry analysis of paraffin-embedded human brain tissue using IFNGR1 (phospho Y457) antibody (ab61062) at 1/50 - 1/100 dilution, in the presence (right panel) or absence (left panel) of phosphopeptide.
  • All lanes : Anti-IFNGR1 (phospho Y457) antibody (ab61062) at 1/500 dilution

    Lane 1 : COS7 cell extract with no phosphopeptide
    Lane 2 : COS7 cell extract with phosphopeptide


    Predicted band size : 54 kDa
    Observed band size : 80 kDa (why is the actual band size different from the predicted?)

Anti-IFNGR1 (phospho Y457) antibody (ab61062)参考文献

ab61062 has not yet been referenced specifically in any publications.

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