Anti-IFNGR1抗体[BB1E2] (FITC) (ab11286)


  • 产品名称Anti-IFNGR1抗体[BB1E2] (FITC)
    参阅全部 IFNGR1 一抗
  • 描述
    小鼠单克隆抗体[BB1E2] to IFNGR1 (FITC)
  • 偶联物FITC. Ex: 493nm, Em: 528nm
  • 特异性This antibody recognises human IFNGR1, expressed by monocytes, and very weakly by resting peripheral blood lymphocytes.
  • 经测试应用适用于: Flow Cytmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Fusion protein of the extracellular part of the human interferon-gamma receptor (AA: Ala17-Gly245) to 11 AA of the c-myc proto-oncogene (for affinity purification).

  • 常规说明This product should be stored undiluted. Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.



Our Abpromise guarantee covers the use of ab11286 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt
  • 应用说明Flow Cyt: Use neat. Use 10µl of the suggested working dilution to label 106 cells in 100µl.
    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Receptor for interferon gamma. Two receptors bind one interferon gamma dimer.
    • 疾病相关Defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]; also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.
    • 序列相似性Belongs to the type II cytokine receptor family.
      Contains 2 fibronectin type-III domains.
      Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    • 翻译后修饰Phosphorylated at Ser/Thr residues.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Antiviral Protein Type II antibody
      • Antiviral protein, type 2 antibody
      • AVP type II antibody
      • AVP, type 2 antibody
      • CD 119 antibody
      • CD119 antibody
      • CD119 antigen antibody
      • CDw119 antibody
      • FLJ45734 antibody
      • IFN gamma R alpha antibody
      • IFN gamma R antibody
      • IFN gamma R1 antibody
      • IFN-gamma receptor 1 antibody
      • IFN-gamma-R1 antibody
      • IFNG R1 antibody
      • IFNGR 1 antibody
      • IFNGR antibody
      • IFNGR1 antibody
      • Immune interferon receptor 1 antibody
      • Immune interferon receptor for antibody
      • INGR1_HUMAN antibody
      • Interferon gamma receptor 1 antibody
      • Interferon gamma receptor alpha chain antibody
      • Interferon gamma receptor alpha chain precursor antibody
      see all

    Anti-IFNGR1 antibody [BB1E2] (FITC) 图像

    • ab11286 staining IFNGR1 in human peripheral blood monocytes by Flow Cytometry analysis.

    Anti-IFNGR1 antibody [BB1E2] (FITC) (ab11286)参考文献

    ab11286 has not yet been referenced specifically in any publications.

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