概述

  • 产品名称Anti-IFNGR1抗体
    参阅全部 IFNGR1 一抗
  • 描述
    兔多克隆抗体to IFNGR1
  • 经测试应用适用于: ELISA, IHC-P, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Synthetic non-phosphopeptide derived from human IFNGR1 around the phosphorylation site of threonine 457 (G-YP-D-K-P).

  • 阳性对照
    • Human brain tissue and COS7 cell extracts.

应用

Our Abpromise guarantee covers the use of ab61179 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/40000.
IHC-P 1/50 - 1/100.
WB 1/500 - 1/1000. Detects a band of approximately 80 kDa (predicted molecular weight: 54 kDa).

靶标

  • 功能Receptor for interferon gamma. Two receptors bind one interferon gamma dimer.
  • 疾病相关Defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]; also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.
  • 序列相似性Belongs to the type II cytokine receptor family.
    Contains 2 fibronectin type-III domains.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • 翻译后修饰Phosphorylated at Ser/Thr residues.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Antiviral Protein Type II antibody
    • Antiviral protein, type 2 antibody
    • AVP type II antibody
    • AVP, type 2 antibody
    • CD 119 antibody
    • CD119 antibody
    • CD119 antigen antibody
    • CDw119 antibody
    • FLJ45734 antibody
    • IFN gamma R alpha antibody
    • IFN gamma R antibody
    • IFN gamma R1 antibody
    • IFN-gamma receptor 1 antibody
    • IFN-gamma-R1 antibody
    • IFNG R1 antibody
    • IFNGR 1 antibody
    • IFNGR antibody
    • IFNGR1 antibody
    • Immune interferon receptor 1 antibody
    • Immune interferon receptor for antibody
    • INGR1_HUMAN antibody
    • Interferon gamma receptor 1 antibody
    • Interferon gamma receptor alpha chain antibody
    • Interferon gamma receptor alpha chain precursor antibody
    see all

Anti-IFNGR1 antibody 图像

  • ab61179 at 1/50 - 1/100 dilution staining IFNGR1 in human brain by Immunohistochemistry, Paraffin-embedded tissue, in the absence or presence of the immunising peptide.
  • All lanes : Anti-IFNGR1 antibody (ab61179) at 1/500 dilution

    Lane 1 : COS7 cell extracts
    Lane 2 : COS7 cell extracts with immunising peptide at 5 µg

    Lysates/proteins at 5 µg per lane.


    Predicted band size : 54 kDa
    Observed band size : 80 kDa (why is the actual band size different from the predicted?)
  • ab61179 staining IFNGR1 in human colon tissue by immunohistochemistry (formalin/PFA-fixed paraffin-embedded sections). Cells were formaldehyde fixed prior to blocking in 10% serum for 2 hours at 21°C. The primary antibody was diluted 1/50 and incubated with the sample for 2 hours at 21°C. Alexa fluor® 594 goat polyclonal, diluted 1/5000, was used as the secondary.

    See Abreview

Anti-IFNGR1 antibody (ab61179)参考文献

This product has been referenced in:
  • Assani K  et al. IFN-? stimulates autophagy-mediated clearance of Burkholderia cenocepacia in human cystic fibrosis macrophages. PLoS One 9:e96681 (2014). WB . Read more (PubMed: 24798083) »
  • Yu KR  et al. A p38 MAPK-mediated alteration of COX-2/PGE2 regulates immunomodulatory properties in human mesenchymal stem cell aging. PLoS One 9:e102426 (2014). WB ; Mouse . Read more (PubMed: 25090227) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"