PE Anti-IFNGR1抗体[2E2] (ab95673)
Key features and details
- PE Armenian hamster monoclonal [2E2] to IFNGR1
- Suitable for: Flow Cyt
- Reacts with: Mouse
- Conjugation: PE. Ex: 488nm, Em: 575nm
- Isotype: IgG
概述
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产品名称
PE Anti-IFNGR1抗体[2E2]
参阅全部 IFNGR1 一抗 -
描述
PE亚美尼亚仓鼠单克隆抗体[2E2] to IFNGR1 -
宿主
Armenian hamster -
偶联物
PE. Ex: 488nm, Em: 575nm -
经测试应用
适用于: Flow Cytmore details -
种属反应性
与反应: Mouse -
免疫原
Purified preparation of soluble recombinant Mouse IFNGR1 chain protein
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阳性对照
- Mouse BALB/c splenocytes
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. -
存储溶液
pH: 7.20
Preservative: 0.09% Sodium azide -
Concentration information loading...
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纯度
Protein G purified -
克隆
单克隆 -
克隆编号
2E2 -
同种型
IgG -
研究领域
相关产品
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab95673于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
Flow Cyt |
Use 1µg for 105 cells.
Cell number should be determined empirically but can range from 105 to 108 cells/test (based on a test volume of 100 µl).
ab101026 - Armenian Hamster monoclonal IgG, is suitable for use as an isotype control with this antibody.
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说明 |
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Flow Cyt
Use 1µg for 105 cells. Cell number should be determined empirically but can range from 105 to 108 cells/test (based on a test volume of 100 µl).
ab101026 - Armenian Hamster monoclonal IgG, is suitable for use as an isotype control with this antibody.
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靶标
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功能
Receptor for interferon gamma. Two receptors bind one interferon gamma dimer. -
疾病相关
Defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]; also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. -
序列相似性
Belongs to the type II cytokine receptor family.
Contains 2 fibronectin type-III domains.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains. -
翻译后修饰
Phosphorylated at Ser/Thr residues. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 15979 Mouse
- SwissProt: P15261 Mouse
- Unigene: 549 Mouse
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别名
- Antiviral Protein Type II antibody
- Antiviral protein, type 2 antibody
- AVP type II antibody
see all
图片
数据表及文件
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Datasheet download
文献 (0)
ab95673 尚未被引用在任何文献中。