概述

  • 产品名称Anti-IFNAR2抗体
    参阅全部 IFNAR2 一抗
  • 描述
    鸡多克隆抗体to IFNAR2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Purified IFNAR2 intra cellular domain recombinant protein (15KD) (Human)

性能

应用

Our Abpromise guarantee covers the use of ab51545 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: 1/500 - 1/5000. Predicted molecular weight: 58 kDa. This antibody was tested using a 15kDA human IFNAR2 recombinant fragment only.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity.
    • 组织特异性Isoform 3 is detected in the urine (at protein level). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines.
    • 序列相似性Belongs to the type II cytokine receptor family.
    • 翻译后修饰Phosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-337 or Tyr-512 are sufficient to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many different cell types.
      Glycosylated.
    • 细胞定位Secreted and Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Human interferon alpha/beta receptor antibody
      • IFN alpha REC antibody
      • IFN R antibody
      • IFN-a/ßR2 antibody
      • IFN-a/ßRß antibody
      • IFN-alpha binding protein antibody
      • IFN-alpha/beta receptor 2 antibody
      • IFN-R-2 antibody
      • IFNABR antibody
      • IFNAR2 antibody
      • IFNARB antibody
      • IFNR antibody
      • INAR2_HUMAN antibody
      • Interferon (alpha beta and omega) receptor 2 antibody
      • Interferon alpha binding protein antibody
      • Interferon alpha/beta receptor 2 antibody
      • Interferon alpha/beta receptor beta chain antibody
      • Type I interferon receptor 2 antibody
      • Type I interferon receptor antibody
      see all

    Anti-IFNAR2 antibody (ab51545)参考文献

    This product has been referenced in:

    See 1 Publication for this product

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