Anti-Iduronate 2 sulfatase抗体(ab85701)


  • 产品名称Anti-Iduronate 2 sulfatase抗体
    参阅全部 Iduronate 2 sulfatase 一抗
  • 描述
    山羊多克隆抗体to Iduronate 2 sulfatase
  • 特异性Expected to recognize isoform A (NP_000193.1).
  • 经测试应用适用于: IHC-P, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide:


    by a Cysteine residue linker, corresponding to internal sequence amino acids 440-451 of Human Iduronate 2 sulfatase (NP_000193.1)

  • 阳性对照
    • Human Liver lysate.



Our Abpromise guarantee covers the use of ab85701 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 3 - 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB Use a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 62 kDa (predicted molecular weight: 62 kDa).


  • 功能Required for the lysosomal degradation of heparan sulfate and dermatan sulfate.
  • 组织特异性Liver, kidney, lung, and placenta.
  • 疾病相关Defects in IDS are the cause of mucopolysaccharidosis type 2 (MPS2) [MIM:309900]; also known as Hunter syndrome. MPS2 is an X-linked lysosomal storage disease characterized by intracellular accumulation of heparan sulfate and dermatan sulfate and their excretion in urine. Most children with MPS2 have a severe form with early somatic abnormalities including skeletal deformities, hepatosplenomegaly, and progressive cardiopulmonary deterioration. A prominent feature is neurological damage that presents as developmental delay and hyperactivity but progresses to mental retardation and dementia. They die before 15 years of age, usually as a result of obstructive airway disease or cardiac failure. In contrast, those with a mild form of MPS2 may survive into adulthood, with attenuated somatic complications and often without mental retardation.
  • 序列相似性Belongs to the sulfatase family.
  • 翻译后修饰The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
  • 细胞定位Lysosome.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Alpha L iduronate sulfate sulfatase antibody
    • Alpha-L-iduronate sulfate sulfatase antibody
    • AW214631 antibody
    • Ids antibody
    • IDS_HUMAN antibody
    • Iduronate 2 sulfatase 14 kDa chain antibody
    • Iduronate 2 sulfatase 42 kDa chain antibody
    • Iduronate 2 sulfatase antibody
    • Iduronate 2-sulfatase 14 kDa chain antibody
    • Iduronate sulfatase antibody
    • Idursulfase antibody
    • MPS2 antibody
    • RP23-29M4.1 antibody
    • SIDS antibody
    see all

Anti-Iduronate 2 sulfatase antibody 图像

  • Anti-Iduronate 2 sulfatase antibody (ab85701) at 0.1 µg/ml + Human Liver lysate at 35 µg

    Predicted band size : 62 kDa
    Observed band size : 62 kDa
  • ab85701 (3.8µg/ml) staining of paraffin embedded Human Placenta shows lysosomal staining of trophoblasts. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Anti-Iduronate 2 sulfatase antibody (ab85701)参考文献

ab85701 has not yet been referenced specifically in any publications.

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