概述

  • 产品名称Anti-IDN3抗体
    参阅全部 IDN3 一抗
  • 描述
    小鼠单克隆抗体to IDN3
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 66-175 of Human IDN3

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • 纯度Protein G purified
  • 克隆单克隆
  • 同种型IgG2a
  • 轻链类型kappa
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab57054 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Probably plays a structural role in chromatin. Involved in sister chromatid cohesion, possibly by interacting with the cohesin complex.
    • 组织特异性Widely expressed. Highly expressed in heart, skeletal muscle, fetal and adult liver, fetal and adult kidney. Expressed at intermediates level in thymus, placenta, peripheral leukocyte and small intestine. Weakly or not expressed in brain, colon, spleen and lung.
    • 疾病相关Cornelia de Lange syndrome 1
    • 序列相似性Belongs to the SCC2/Nipped-B family.
      Contains 5 HEAT repeats.
    • 发展阶段In embryos, it is expressed in developing limbs and later in cartilage primordia of the ulna and of various hand bones. Sites of craniofacial expression include the cartilage primordium of the basioccipital and basisphenoid skull bones and elsewhere in the head and face, including a region encompassing the mesenchyme adjacent to the cochlear canal. Also expressed in the spinal column, notochord and surface ectoderm sclerotome and what seem to be migrating myoblasts. Expressed in the developing heart in the atrial and ventricular myocardium and in the ventricular tubeculae but absent in the endocardial cushions. Also expressed in the developing esophagus, trachea and midgut loops, in the bronchi of the lung and in the tubules of the metanephros. Expression in organs and tissues not typically affected in CDL (e.g. the developing trachea, bronchi, esophagus, heart and kidney) may reflect a bias towards underreporting of more subtle aspects of the phenotype or problems that typically present later in life. Expressed in the mesenchyme surrounding the cochlear canal possibly reflecting the hearing impairment commonly found. Weakly or not expressed in embryonic brain.
    • 结构域Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 形式There are 3 isoforms produced by alternative splicing. Isoform 1 also known as: A; IDN3-A. Isoform 2 also known as: B; IDN3-B.
    • 别名
      • CDLS antibody
      • Colon tumor susceptibility 2 antibody
      • Delangin antibody
      • DKFZp434L1319 antibody
      • FLJ11203 antibody
      • FLJ12597 antibody
      • FLJ13354 antibody
      • FLJ13648 antibody
      • FLJ44854 antibody
      • IDN 3 antibody
      • IDN 3 protein antibody
      • IDN 3 protein isoform A antibody
      • IDN 3 protein isoform B antibody
      • IDN 3B antibody
      • IDN3 B antibody
      • IDN3 protein antibody
      • IDN3 protein isoform A antibody
      • IDN3 protein isoform B antibody
      • IDN3B antibody
      • Mis 4 antibody
      • Mis4 antibody
      • Nipbl antibody
      • NIPBL_HUMAN antibody
      • Nipped B homolog (Drosophila) antibody
      • Nipped B homolog antibody
      • Nipped B like antibody
      • Nipped B like protein antibody
      • Nipped-B-like protein antibody
      • Scc 2 antibody
      • SCC 2 homolog antibody
      • Scc2 antibody
      • SCC2 homolog antibody
      • Sister chromatid cohesion protein Mis4 antibody
      see all

    Anti-IDN3 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab57054 IDN3 antibody at 1ug/ml. Predicted band size of immunogen is 35 kDa

    Anti-IDN3 antibody (ab57054)参考文献

    ab57054 has not yet been referenced specifically in any publications.

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