重组
RabMAb

Anti-ICOS Ligand抗体[EPR6071] (ab124972)

概述

  • 产品名称
    Anti-ICOS Ligand抗体[EPR6071]
    参阅全部 ICOS Ligand 一抗
  • 描述
    兔单克隆抗体[EPR6071] to ICOS Ligand
  • 宿主
    Rabbit
  • 经测试应用
    适用于: WB, ICC/IFmore details
    不适用于: Flow Cyt,IHC-P or IP
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide within Human ICOS Ligand aa 250-350 (intracellular). The exact sequence is proprietary.

  • 阳性对照
    • HL60, HuT78 and HUVEC (untreated or treated with TNF-alpha) lysates.
  • 常规说明

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

    We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result of this work we are pleased to now offer this antibody in purified format. We are in the process of updating our datasheets. The purified format is designated 'PUR' on our product labels. If you have any questions regarding this update, please contact our Scientific Support team.

    This product is a recombinant rabbit monoclonal antibody.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • 解离常数(KD
    KD = 8.80 x 10 -11 M
    Learn more about KD
  • 存储溶液
    pH: 7.20
    Preservative: 0.01% Sodium azide
    Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
  • Concentration information loading...
  • 纯度
    Protein A purified
  • 克隆
    单克隆
  • 克隆编号
    EPR6071
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab124972 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Detects a band of approximately 63 - 72 kDa (predicted molecular weight: 33 kDa).
ICC/IF 1/50 - 1/100.
  • 应用说明
    Is unsuitable for Flow Cyt,IHC-P or IP.
  • 靶标

    • 功能
      Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.
    • 组织特异性
      Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells.
    • 序列相似性
      Belongs to the immunoglobulin superfamily. BTN/MOG family.
      Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
      Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    • 细胞定位
      Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • B7 H2 antibody
      • B7 homolog 2 antibody
      • B7 homologue 2 antibody
      • B7 like protein Gl50 antibody
      • B7 related protein 1 antibody
      • B7-H2 antibody
      • B7-like protein Gl50 antibody
      • B7-related protein 1 antibody
      • B7H2 antibody
      • B7RP 1 antibody
      • B7RP-1 antibody
      • B7RP1 antibody
      • CD 275 antibody
      • CD275 antibody
      • CD275 antigen antibody
      • GL 50 antibody
      • GL50 antibody
      • ICOS L antibody
      • ICOS LG antibody
      • ICOS ligand antibody
      • ICOSL antibody
      • ICOSL_HUMAN antibody
      • Icoslg antibody
      • Inducible T cell co stimulator ligand antibody
      • KIAA0653 antibody
      • LICOS antibody
      • Transmembrane protein B7 H2 ICOS ligand antibody
      see all

    图片

    • All lanes : Anti-ICOS Ligand antibody [EPR6071] (ab124972) at 1/1000 dilution

      Lane 1 : HL60 cell lysate
      Lane 2 : HuT78 cell lysate
      Lane 3 : HUVEC cell lysate, treated with TNF-alpha
      Lane 4 : HUVEC cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : Goat anti-Rabbit HRP at 1/2000 dilution

      Predicted band size: 33 kDa

    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

    文献

    ab124972 has not yet been referenced specifically in any publications.

    客户评价及客户问答

    There are currently no Customer reviews or Questions for ab124972.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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