RabMAb

Anti-ICOS Ligand抗体[EPR6071] (ab124972)

概述

  • 产品名称Anti-ICOS Ligand抗体[EPR6071]
    参阅全部 ICOS Ligand 一抗
  • 描述
    兔单克隆抗体[EPR6071] to ICOS Ligand
  • 经测试应用适用于: WB, ICC/IFmore details
    不适用于: Flow Cyt,IHC-P or IP
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide, corresponding to residues in the intracellular domain of Human ICOS Ligand.

  • 阳性对照
    • HL60, HuT78 and HUVEC (untreated or treated with TNF-alpha) lysates.
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • 解离常数(KD KD = 8.80 x 10 -11 M Learn more about KD
  • 存储溶液pH: 7.20
    Preservative: 0.01% Sodium azide
    Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
  • 纯度Tissue culture supernatant
  • 克隆单克隆
  • 克隆编号EPR6071
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab124972 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Detects a band of approximately 63 - 72 kDa (predicted molecular weight: 33 kDa).
ICC/IF 1/50 - 1/100.
  • 应用说明Is unsuitable for Flow Cyt,IHC-P or IP.
  • 靶标

    • 功能Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.
    • 组织特异性Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells.
    • 序列相似性Belongs to the immunoglobulin superfamily. BTN/MOG family.
      Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
      Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • B7 H2 antibody
      • B7 homolog 2 antibody
      • B7 homologue 2 antibody
      • B7 like protein Gl50 antibody
      • B7 related protein 1 antibody
      • B7-H2 antibody
      • B7-like protein Gl50 antibody
      • B7-related protein 1 antibody
      • B7H2 antibody
      • B7RP 1 antibody
      • B7RP-1 antibody
      • B7RP1 antibody
      • CD 275 antibody
      • CD275 antibody
      • CD275 antigen antibody
      • GL 50 antibody
      • GL50 antibody
      • ICOS L antibody
      • ICOS LG antibody
      • ICOS ligand antibody
      • ICOSL antibody
      • ICOSL_HUMAN antibody
      • Icoslg antibody
      • Inducible T cell co stimulator ligand antibody
      • KIAA0653 antibody
      • LICOS antibody
      • Transmembrane protein B7 H2 ICOS ligand antibody
      see all

    Anti-ICOS Ligand antibody [EPR6071] 图像

    • All lanes : Anti-ICOS Ligand antibody [EPR6071] (ab124972) at 1/1000 dilution

      Lane 1 : HL60 cell lysate
      Lane 2 : HuT78 cell lysate
      Lane 3 : HUVEC cell lysate, treated with TNF-alpha
      Lane 4 : HUVEC cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      Goat anti-Rabbit HRP at 1/2000 dilution

      Predicted band size : 33 kDa
    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

    Anti-ICOS Ligand antibody [EPR6071] (ab124972)参考文献

    ab124972 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"