ICI 118551 hydrochloride (ab120808)

概述

  • 产品名称ICI 118551 hydrochloride
  • 描述
    Highly selective β2 adrenoceptor antagonist
  • 生物学描述Highly selective β2 adrenoceptor antagonist (Ki values are 1.2, 120 and 257 nM at β2, β1 and β3 receptors, respectively). Blood-brain barrier permeable. Decreases vascular tone in vivo.
  • 纯度> 99%

性能

  • 化学名称(2R*,3R*)-1-[(2,3-Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol
  • 分子量313.87
  • 化学结构Chemical Structure
  • 分子式C17H27NO2.HCl
  • CAS编号72795-01-8
  • 存放说明Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • 溶解度概述Soluble in water to 10 mM and in DMSO to 10 mM
  • 处理

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • 来源

    Synthetic

  • 研究领域

    ICI 118551 hydrochloride (ab120808)参考文献

    This product has been referenced in:
    • Wenzel D  et al. beta(2)-adrenoceptor antagonist ICI 118,551 decreases pulmonary vascular tone in mice via a G(i/o) protein/nitric oxide-coupled pathway. Hypertension 54:157-63 (2009). Read more (PubMed: 19470879) »
    • Ahmad S  et al. Characterization of beta adrenoceptors on cultured endothelial cells by radioligand binding. Life Sci 47:2365-70 (1990). Read more (PubMed: 1979829) »
    • Bilski AJ  et al. The pharmacology of a beta 2-selective adrenoceptor antagonist (ICI 118,551). J Cardiovasc Pharmacol 5:430-7 (0). Read more (PubMed: 6191142) »

    See 0 Publications for this product

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