概述

  • 产品名称Anti-IBRDC2抗体
    参阅全部 IBRDC2 一抗
  • 描述
    小鼠单克隆抗体to IBRDC2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: MGSAGRLHYL AMTAENPTPG DLAPAPLITC KLCLCEQSLD KMTTLQECQC IFCTACLKQY MQLAIREGCG SPITCPDMVC LNHGTLQEAE IACLVPVDQF , corresponding to amino acids 1-101 of Human IBRDC2

性能

应用

Our Abpromise guarantee covers the use of ab57246 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.
    • 组织特异性Broadly expressed, with lowest levels in brain and thymus, and highest levels detectable in heart, ovary and testis.
    • 通路Protein modification; protein ubiquitination.
    • 序列相似性Belongs to the RBR family. RNF144 subfamily.
      Contains 1 IBR-type zinc finger.
      Contains 2 RING-type zinc fingers.
    • 结构域The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme (By similarity). The transmembrane domain is essential for translocation to the mitochondria upon induction of apoptosis.
    • 翻译后修饰Auto-ubiquitinated.
    • 细胞定位Mitochondrion membrane. Cytoplasm. Mostly cytosololic, accumulates in submitochondrial domains specifically upon apoptosis induction, in synchrony with BAX activation.
    • Information by UniProt
    • 数据库链接
    • 别名
      • bA528A10.3 antibody
      • E3 ubiquitin protein ligase RNF144B antibody
      • E3 ubiquitin-protein ligase RNF144B antibody
      • IBR domain containing 2 antibody
      • IBR domain containing protein 2 antibody
      • IBR domain-containing protein 2 antibody
      • IBRDC 2 antibody
      • IBRDC2 antibody
      • KIAA0161 antibody
      • MGC71786 antibody
      • OTTHUMP00000016079 antibody
      • OTTHUMP00000016080 antibody
      • OTTHUMP00000039360 antibody
      • p53 inducible RING finger protein antibody
      • p53-inducible RING finger protein antibody
      • p53RFP antibody
      • PIR2 antibody
      • R144B_HUMAN antibody
      • Ring finger 144B antibody
      • RING finger protein 144B antibody
      • RNF 144B antibody
      • RNF144B antibody
      see all

    Anti-IBRDC2 antibody 图像



    • Predicted band size : 34 kDa

    Anti-IBRDC2 antibody (ab57246)参考文献

    This product has been referenced in:
    • Du W  et al. Cytoplasmic FANCA-FANCC complex interacts and stabilizes the cytoplasm-dislocalized leukemic nucleophosmin protein (NPMc). J Biol Chem 285:37436-44 (2010). WB ; Human . Read more (PubMed: 20864535) »

    See 1 Publication for this product

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