概述

  • 产品名称Ibotenic acid
  • 描述
    Excitotoxic agonist
  • 生物学描述Neuroexcitatory amino acid originally isolated from Amanita species. Neurotoxin often used to model cognitive dysfunctions. NMDA and metabotropic receptor agonist.

    Also available in simple stock solutions (ab146670) - add 1 ml of water to get an exact, ready-to-use concentration.
  • 纯度> 98%

性能

    Ibotenic acid 图像

    • Representative examples of NeuN immunohistochemistry of a complete auditory cortex lesion or sham-operated control section. Rats were anesthetized with halothane and placed in a Kopf stereotaxic apparatus. The skin overlying the skull was disinfected, an incision made, and small burr holes drilled through the skull bone to allow penetration of the injector (Hamilton 1 µl syringe). Bilateral excitotoxic lesions (two per side) were produced by injections of 0.25 µl ibotenic acid (10 µg/µl in 0.1 M sodium phosphate buffer, pH: 7.4; ab120041). The rate of infusion was 0.05 µl/min. The injector was lowered in the brain and left in place 3 min before and 5 min after each injection.

    Ibotenic acid (ab120041)参考文献

    This product has been referenced in:
    • Eijkenboom M  et al. Modelling cognitive dysfunctions with bilateral injections of ibotenic acid into the rat entorhinal cortex. Neuroscience 101:27-39 (2000). Read more (PubMed: 11068134) »
    • Inglis WL & Semba K Discriminable excitotoxic effects of ibotenic acid, AMPA, NMDA and quinolinic acid in the rat laterodorsal tegmental nucleus. Brain Res 755:17-27 (1997). Read more (PubMed: 9163537) »

    See all 6 Publications for this product

    Product Wall

    Thank you very much for your call last week and for your patience while I've been discussing this issue with the lab.

    Our chemists have re-tested the solubility, and they found that ab120041 was soluble to 10 mM in water and PBS buffer. To ac...

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    Thank you for contacting Abcam yesterday about ab120041.

    This compound is normally shipped at room temperature. As this product is shipped at ambient temperature it is considered to be stable for the duration of shipping and normal handling. ...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"