Anti-iASPP抗体[LXO49.3] (ab49805)

概述

  • 产品名称Anti-iASPP抗体[LXO49.3]
    参阅全部 iASPP 一抗
  • 描述
    小鼠单克隆抗体[LXO49.3] to iASPP
  • 经测试应用适用于: WB, ICC, IPmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 459-639 of Human iASPP

  • 阳性对照
    • Total cell extract of human osteogenic sarcoma (U-2-OS)

性能

应用

Our Abpromise guarantee covers the use of ab49805 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.1 - 0.2 µg/ml. Predicted molecular weight: 92 kDa.
ICC Use at an assay dependent dilution.
IP Use at an assay dependent dilution.

靶标

  • 相关性ASPP proteins (ASPP1, ASPP2 and iASPP) represent a new family of p53 binding proteins. ASPP1 and ASPP2 bind and enhance p53-mediated apoptosis. In contrast, the third member, iASPP, functionally inactivates p53. iASPP (also called protein phosphatase 1 regulatory (inhibitor) subunit 13 like protein, Inhibitor of ASPP protein, Protein iASPP, PPP1R13B-like protein and NFkB-interacting protein 1) plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. iASPP blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. This protein also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis. iASPP is predominantly a cytoplasmic protein (isoform 1) but can also be found in the nucleus (isoform 2). iASPP is highly expressed in heart, placenta and prostate and is weakly expressed in brain, liver, skeletal muscle, testis and peripheral blood leukocyte. The N-terminal region of isoform 1 is required for cytoplasmic localization. Defects in iASPP may be a cause of certain breast cancers and the protein is overexpressed in many patients suffering from breast carcinomas and expressing a wild-type p53/TP53 protein.
  • 细胞定位Nuclear
  • 数据库链接
  • 别名
    • IASPP antibody
    • inhibitor of apoptosis stimulating protein of p53 antibody
    • Inhibitor of ASPP protein antibody
    • NFkB interacting protein 1 antibody
    • NKIP1 antibody
    • PPP1R13B-like protein antibody
    • PPP1R13L antibody
    • Protein iASPP antibody
    • protein phosphatase 1 regulatory (inhibitor) subunit 13 like antibody
    • RAI antibody
    • RelA-associated inhibitor antibody
    see all

Anti-iASPP antibody [LXO49.3] (ab49805)参考文献

ab49805 has not yet been referenced specifically in any publications.

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