重组Anti-HYAL1抗体[EPR5542] (ab180143)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR5542] to HYAL1
- Suitable for: WB
- Reacts with: Human
Related conjugates and formulations
概述
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产品名称
Anti-HYAL1抗体[EPR5542]
参阅全部 HYAL1 一抗 -
描述
兔单克隆抗体[EPR5542] to HYAL1 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide within Human HYAL1 aa 350 to the C-terminus (C terminal). The exact sequence is proprietary.
Database link: Q12794 -
阳性对照
- HepG2, LnCap and HT-1376 cell lysates.
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常规说明
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.2
Preservative: 0.01% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.5% BSA -
Concentration information loading...
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纯度
Protein A purified -
克隆
单克隆 -
克隆编号
EPR5542 -
同种型
IgG -
研究领域
相关产品
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Alternative Versions
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Isotype control
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Positive Controls
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab180143于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/1000. Detects a band of approximately 60 kDa (predicted molecular weight: 48 kDa).
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说明 |
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WB
1/1000. Detects a band of approximately 60 kDa (predicted molecular weight: 48 kDa). |
靶标
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功能
May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth. -
组织特异性
Highly expressed in the liver, kidney and heart. Weakly expressed in lung, placenta and skeletal muscle. No expression detected in adult brain. Isoform 1 is expressed only in bladder and prostate cancer cells, G2/G3 bladder tumor tissues and lymph node specimens showing tumor invasive tumors cells. Isoform 3, isoform 4, isoform 5 and isoform 6 are expressed in normal bladder and bladder tumor tissues. -
疾病相关
Defects in HYAL1 are the cause of mucopolysaccharidosis type 9 (MPS9) [MIM:601492]; also called hyaluronidase deficiency. MPS9 is a lysosomal storage disease characterized by high hyaluronan (HA) concentration in the serum. The clinical features are periarticular soft tissue masses, mild short stature and acetabular erosions, and absence of neurological or visceral involvement. -
序列相似性
Belongs to the glycosyl hydrolase 56 family.
Contains 1 EGF-like domain. -
细胞定位
Secreted. Lysosome. - Information by UniProt
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数据库链接
- Entrez Gene: 3373 Human
- Omim: 607071 Human
- SwissProt: Q12794 Human
- Unigene: 75619 Human
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别名
- HYAL 1 antibody
- Hyal-1 antibody
- HYAL1 antibody
see all
图片
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All lanes : Anti-HYAL1 antibody [EPR5542] (ab180143) at 1/1000 dilution
Lane 1 : HepG2 cell lysate
Lane 2 : LnCap cell lysate
Lane 3 : HT-1376 cell lysate
Lysates/proteins at 10 µg per lane.
Secondary
All lanes : Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution
Predicted band size: 48 kDa
Observed band size: 60 kDa why is the actual band size different from the predicted?Blocking buffer and concentration: 5%NFDM/TBST
数据表及文件
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SDS download
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Datasheet download
Certificate of Compliance
文献 (0)
ab180143 尚未被引用在任何文献中。