概述

  • 产品名称
    Anti-HYAL1抗体
    参阅全部 HYAL1 一抗
  • 描述
    兔多克隆抗体to HYAL1
  • 宿主
    Rabbit
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 50 - 150 of Human HYAL1.

    参阅Abcam的专有抗源政策

  • 阳性对照
    • This antibody gave a positive signal in the following Human tissue lysates: Liver; Kidney; Heart; Breast.

性能

应用

Our Abpromise guarantee covers the use of ab96751 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 45 kDa (predicted molecular weight: 48 kDa).

靶标

  • 功能
    May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.
  • 组织特异性
    Highly expressed in the liver, kidney and heart. Weakly expressed in lung, placenta and skeletal muscle. No expression detected in adult brain. Isoform 1 is expressed only in bladder and prostate cancer cells, G2/G3 bladder tumor tissues and lymph node specimens showing tumor invasive tumors cells. Isoform 3, isoform 4, isoform 5 and isoform 6 are expressed in normal bladder and bladder tumor tissues.
  • 疾病相关
    Defects in HYAL1 are the cause of mucopolysaccharidosis type 9 (MPS9) [MIM:601492]; also called hyaluronidase deficiency. MPS9 is a lysosomal storage disease characterized by high hyaluronan (HA) concentration in the serum. The clinical features are periarticular soft tissue masses, mild short stature and acetabular erosions, and absence of neurological or visceral involvement.
  • 序列相似性
    Belongs to the glycosyl hydrolase 56 family.
    Contains 1 EGF-like domain.
  • 细胞定位
    Secreted. Lysosome.
  • Information by UniProt
  • 数据库链接
    • 别名
      • HYAL 1 antibody
      • Hyal-1 antibody
      • HYAL1 antibody
      • HYAL1_HUMAN antibody
      • Hyaluronidase 1 antibody
      • Hyaluronidase-1 antibody
      • Hyaluronoglucosaminidase 1 antibody
      • Hyaluronoglucosaminidase-1 antibody
      • Hyaluronoglucosaminidase1 antibody
      • LUCA 1 antibody
      • LUCA-1 antibody
      • LUCA1 antibody
      • Lung carcinoma protein 1 antibody
      • MGC45987 antibody
      • NAT6 antibody
      • Plasma hyaluronidase antibody
      • Tumor suppressor LUCA 1 antibody
      see all

    图片

    • Western blot - Anti-HYAL1 antibody (ab96751)
      Western blot - Anti-HYAL1 antibody (ab96751)
      All lanes : Anti-HYAL1 antibody (ab96751) at 1 µg/ml

      Lane 1 : Human liver tissue lysate - total protein (ab29889)
      Lane 2 : Human kidney tissue lysate - total protein (ab30203)
      Lane 3 : Human heart tissue lysate - total protein (ab29431)
      Lane 4 : Human breast tissue lysate - total protein (ab30090)

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution

      Developed using the ECL technique.

      Performed under reducing conditions.

      Predicted band size: 48 kDa
      Observed band size: 45 kDa (why is the actual band size different from the predicted?)
      Additional bands at: 60 kDa. We are unsure as to the identity of these extra bands.


      Exposure time: 4 minutes


      The band observed at 45 kDa could potentially be a cleaved form of HYAL1 due to the presence of a 21 amino acid signal peptide.

    实验方案

    文献

    ab96751 has not yet been referenced specifically in any publications.

    发表研究结果有使用 ab96751？请让我们知道，以便我们可以引用本数据表中的参考文章。

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