Anti-HVCN1抗体(ab117520)

概述

  • 产品名称Anti-HVCN1抗体
    参阅全部 HVCN1 一抗
  • 描述
    兔多克隆抗体to HVCN1
  • 经测试应用适用于: WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to C terminal amino acids of Human HVCN1 (NP_115745.2).

  • 阳性对照
    • Human spleen and thymus tissues.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab117520 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 32 kDa.Can be blocked with HVCN1 peptide (ab214795).
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 5 µg/ml.

靶标

  • 功能Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis.
  • 组织特异性Enriched in immune tissues, such as lymph nodes, B-lymphocytes, monocytes and spleen.
  • 序列相似性Belongs to the hydrogen channel family.
  • 结构域The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Unlike other voltage-gated ion channels it lacks the pore domain.
    The C-terminal coiled coil region mediates homodimerization and cooperative channel gating. It is essential for normal subcellular localization.
  • 翻译后修饰Phosphorylation may enhance channel gating.
  • 细胞定位Membrane. Cell membrane. Detected mainly at intracellular membranes upon overexpression in HeLa cells (PuMed:20147290), but not in other cell types.
  • Information by UniProt
  • 数据库链接
  • 别名
    • HV 1 antibody
    • HV1 antibody
    • HVCN 1 antibody
    • HVCN1 antibody
    • HVCN1_HUMAN antibody
    • Hydrogen voltage gated channel 1 antibody
    • Hydrogen voltage-gated channel 1 antibody
    • Voltage gated hydrogen channel 1 antibody
    • Voltage sensor domain only protein antibody
    • Voltage sensor domain-only protein antibody
    • Voltage-gated hydrogen channel 1 antibody
    • VSOP antibody
    see all

Anti-HVCN1 antibody 图像

  • ab117520, at 5 µg/ml, staining HVCN1 in Formalin-fixed, Paraffin-embedded Human spleen tissue by Immunohistochemistry.
  • ab117520, at 5 µg/ml, staining HVCN1 in Formalin-fixed, Paraffin-embedded Human thymus tissue by Immunohistochemistry.

Anti-HVCN1 antibody (ab117520)参考文献

ab117520 has not yet been referenced specifically in any publications.

Product Wall

I am sorry for any confusion.

This protocol is provided from the lab which supplies ab117520 directly to us. It is the same protocol they use to test all their antibodies in IHC butrest assured it is not arandom protocol from IHC world.
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Thank you for your enquiry. Below please find the IHC protocol requested.

I hope this is helpful. Please contact me again if you have any further questions.

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Tissue Preparation

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"