概述

  • 产品名称Anti-HUS1抗体
    参阅全部 HUS1 一抗
  • 描述
    兔多克隆抗体to HUS1
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rat, Cow, Pig
  • 免疫原

    Recombinant protein fragment containing a sequence corresponding to a region within amino acids 1 - 243 of Human HUS1 (AAH07013).

  • 阳性对照
    • 293T cell lysate, CA922 xenograft

性能

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应用

Our Abpromise guarantee covers the use of ab96297 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 32 kDa.
IHC-P 1/100 - 1/500.

靶标

  • 功能Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates.
  • 组织特异性Ubiquitous.
  • 序列相似性Belongs to the HUS1 family.
  • 细胞定位Nucleus. Cytoplasm. In discrete nuclear foci upon DNA damage. According to PubMed:14500360, localized also in the cytoplasm. DNA damage induces its nuclear translocation. Shuttles between the nucleus and the cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Checkpoint protein HUS1 antibody
    • hHUS1 antibody
    • HUS1 (S. pombe) checkpoint homolog antibody
    • Hus1 antibody
    • HUS1 checkpoint homolog (S. pombe) antibody
    • HUS1 Checkpoint Protein antibody
    • HUS1 protein antibody
    • HUS1+ - like protein antibody
    • HUS1_HUMAN antibody
    • Hydroxyurea-sensitive 1, S. pombe, homolog of antibody
    see all

Anti-HUS1 antibody 图像

  • Anti-HUS1 antibody (ab96297) at 1/1000 dilution + 293T whole cell lysate at 30 µg

    Predicted band size : 32 kDa
  • ab96297 at 1/500 dilution, staining HUS1 in paraffin-embedded CA922 xenograft.

Anti-HUS1 antibody (ab96297)参考文献

This product has been referenced in:

See 1 Publication for this product

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