概述

描述

  • 性质
    Synthetic
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      RRRNVRGEDSGRKPERRRLK
    • 氨基酸
      279 to 298

技术指标

Our Abpromise guarantee covers the use of ab8383 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    PBS with 0.1% BSA 0.02% sodium azide pH7.2

常规信息

  • 别名
    • DAP kinase 3
    • DAP like kinase
    • DAP-like kinase
    • Dapk 3
    • DAPK3
    • DAPK3_HUMAN
    • Death associated kinase 3
    • Death associated protein kinase 3
    • Death-associated protein kinase 3
    • Dlk
    • EC 2.7.11.1
    • FLJ36473
    • MYPT1 kinase
    • ZIP
    • ZIP kinase
    • ZIP kinase isoform
    • ZIP-kinase
    • ZIPK
    • zipper-interacting protein kinase
    see all
  • 功能
    Serine/threonine kinase which acts as a positive regulator of apoptosis. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. Regulates myosin light chain phosphatase through phosphorylation of MYPT1 thereby regulating the assembly of the actin cytoskeleton, cell migration, invasiveness of tumor cells, smooth muscle contraction and neurite outgrowth. Involved in the formation of promyelocytic leukemia protein nuclear body (PML-NB), one of many subnuclear domains in the eukaryotic cell nucleus, and which is involved in oncogenesis and viral infection.
  • 序列相似性
    Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.
    Contains 1 protein kinase domain.
  • 翻译后修饰
    Ubiquitinated. Ubiquitination mediated by the UBE2D3 E3 ligase does not lead to proteasomal degradation, but influences promyelocytic leukemia protein nuclear bodies (PML-NBs) formation in the nucleus.
    Autophosphorylated. Phosphorylated by ROCK1.
  • 细胞定位
    Nucleus. Cytoplasm. Nucleus > PML body. Relocates to the cytoplasm on binding PAWR where the complex appears to interact with actin filaments (By similarity). Localizes to promyelocytic leukemia protein nuclear bodies (PML-NBs). Associates to centromeres from prophase to anaphase.
  • Information by UniProt

Human ZIP Kinase peptide (ab8383)参考文献

ab8383 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab8383.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

注册