概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列RERCPHPPRGNVSE
    • 氨基酸1503 to 1516

相关产品

技术指标

Our Abpromise guarantee covers the use of ab23172 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-ZCH11 antibody (ab9940)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • DKFZp779C1943
    • EC 2.7.7.52
    • FLJ42878
    • KIAA0191
    • PAP associated domain containing 3
    • PAPD3
    • Terminal uridylyltransferase 4
    • TUT4
    • TUT4_HUMAN
    • TUTase 4
    • ZCCHC 11
    • Zcchc11
    • Zinc finger CCHC domain containing 11
    • Zinc finger CCHC domain containing protein 11
    • Zinc finger CCHC domain-containing protein 11
    see all
  • 功能Uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. Catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency. Does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28A and LIN28B. Also catalyzes the 3' uridylation of miR-26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression. May also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation.
  • 序列相似性Belongs to the DNA polymerase type-B-like family.
    Contains 3 CCHC-type zinc fingers.
    Contains 2 PAP-associated domains.
  • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Nucleus. Cytoplasm. Translocates into the cytoplasm following treatment of the cell with LPS.
  • Information by UniProt

Human ZCH11 peptide (ab23172)参考文献

ab23172 has not yet been referenced specifically in any publications.

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