概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列CEKERYYKFKRFHF
    • 氨基酸305 to 317

相关产品

技术指标

Our Abpromise guarantee covers the use of ab39906 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    Blocking

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

常规信息

  • 别名
    • BIRC 4 binding protein
    • BIRC4 binding protein
    • BIRC4-binding protein
    • BIRC4BP
    • HSXIAPAF 1
    • HSXIAPAF1
    • XAF 1
    • XAF1
    • XAF1_HUMAN
    • XIAP associated factor 1
    • XIAP-associated factor 1
    • XIAPAF1
    see all
  • 功能Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells.
  • 组织特异性Widely expressed. Expression is frequently down-regulated in cancer cell lines. Isoform 5 is widely expressed. Expressed in placenta (at protein level).
  • 序列相似性Contains 1 TRAF-type zinc finger.
  • 发展阶段Selectively expressed in third trimester placenta.
  • 细胞定位Nucleus and Cytoplasm. Nucleus. Mitochondrion. Found in the cytoplasm and nucleus of placental syncytiotrophoblasts. Translocates to mitochondria upon TNF-alpha treatment.
  • Information by UniProt

Human XAF1 peptide (ab39906)参考文献

ab39906 has not yet been referenced specifically in any publications.

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