The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
CDC42 like GTPase
CDC42-like GTPase 1
GTP binding protein like 1
GTP binding protein SB128
GTP-binding protein-like 1
Ras homolog gene family member U
Ras homolog gene family member U isoform CRA a
Ras like gene family member U
Rho GTPase like protein ARHU
Rho GTPase-like protein ARHU
Rho related GTP binding protein RhoU
Rho-related GTP-binding protein RhoU
Wnt-1 responsive Cdc42 homolog 1
Wnt1 responsive Cdc42 homolog
功能Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound.
组织特异性Ubiquitously expressed in all tissues examined. Expressed at high levels in the stomach, small intestine, brain, skeletal muscle and placenta.
序列相似性Belongs to the small GTPase superfamily. Rho family.
细胞定位Cell membrane. Golgi apparatus membrane. Cell junction > focal adhesion. Cell projection > podosome. Localizes to podosomes in SRC-transformed cells.