概述

描述

  • 性质
    Synthetic
  • 氨基酸序列
    • 种属
      Human
    • 序列
      C-SNWLYLAKLSSVGS
    • 氨基酸
      23 to 36

技术指标

Our Abpromise guarantee covers the use of ab23258 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • MGC123964
    • Protein Wnt-4
    • RP23-246F18.1
    • SERKAL
    • Wingless type MMTV integration site family member 4 precursor
    • WNT 4
    • WNT 4 protein precursor
    • WNT4
    • WNT4_HUMAN
    see all
  • 功能
    Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). Overexpression may be associated with abnormal proliferation in human breast tissue.
  • 疾病相关
    Defects in WNT4 are a cause of Rokitansky-Kuster-Hauser syndrome (RKH syndrome) [MIM:277000]; also called Mayer-Rokitansky-Kuster-Hauser syndrome (MRKH syndrome or MRKH anomaly). RKH syndrome is characterized by utero-vaginal atresia in otherwise phenotypically normal female with a normal 46,XX karyotype. Anomalies of the genital tract range from upper vaginal atresia to total Muellerian agenesis with urinary tract abnormalities. It has an incidence of approximately 1 in 5'000 newborn girls.
    Defects in WNT4 are the cause of female sex reversal with dysgenesis of kidneys, adrenals, and lungs (SERKAL) [MIM:611812]; also known as SERKAL syndrome.
    Defects in WNT4 are the cause of Muellerian aplasia (MULLAPL) [MIM:158330].
  • 序列相似性
    Belongs to the Wnt family.
  • 细胞定位
    Secreted > extracellular space > extracellular matrix.
  • Information by UniProt

文献

This product has been referenced in:
  • Miyakoshi T  et al. The expression of Wnt4 is regulated by estrogen via an estrogen receptor alpha-dependent pathway in rat pituitary growth hormone-producing cells. Acta Histochem Cytochem 42:205-13 (2009). Blocking . Read more (PubMed: 20126574) »

See 1 Publication for this product

客户评价及客户问答

Thank you for your enquiry. Ab23258 is the immunizing peptide that was used to generate Ab15699; which is one of our Fast Track products. The peptide will only have been used to test our "Fast Track" product for peptide ELISA. Ab23258 has not been t...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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