概述

  • 产品名称
    人VDAC1 / Porin肽

描述

  • 性质
    Synthetic
  • 氨基酸序列
    • 种属
      Human

技术指标

Our Abpromise guarantee covers the use of ab95341 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 纯度
    70 - 90% by HPLC.

  • 形式
    Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

  • 复溶
    Reconstitute with sterile distilled water

常规信息

  • 别名
    • hVDAC1
    • Outer mitochondrial membrane protein porin 1
    • Plasmalemmal porin
    • Porin
    • Porin 31HL
    • Porin 31HM
    • VDAC
    • VDAC 1
    • VDAC-1
    • Vdac1
    • VDAC1_HUMAN
    • Voltage Dependent Anion Channel 1
    • Voltage dependent anion selective channel protein 1
    • Voltage-dependent anion-selective channel protein 1
    see all
  • 功能
    Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
  • 组织特异性
    Heart, liver and skeletal muscle.
  • 序列相似性
    Belongs to the eukaryotic mitochondrial porin family.
  • 结构域
    Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. The helical N-terminus folds back into the pore opening and plays a role in voltage-gated channel activity.
  • 细胞定位
    Mitochondrion outer membrane. Cell membrane.
  • Information by UniProt

文献

ab95341 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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