The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Deubiquitinating enzyme 3
Ubiquitin carboxyl-terminal hydrolase 3
Ubiquitin specific peptidase 3
Ubiquitin specific processing protease 3
Ubiquitin Specific Protease 3
Ubiquitin thioesterase 3
Ubiquitin thiolesterase 3
Ubiquitin-specific-processing protease 3
功能Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin.
组织特异性Expressed in all tissues examined, with strongest expression in pancreas.
序列相似性Belongs to the peptidase C19 family. USP3 subfamily. Contains 1 UBP-type zinc finger.
结构域Both protease activity and an intact zinc finger are required for H2A monodeubiquitination.
细胞定位Nucleus. Localizes preferentially with monoubiquitinated H2A to chromatin.