概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列GKKRTKGKTVPIDD-C
    • 氨基酸2 to 15

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技术指标

Our Abpromise guarantee covers the use of ab23059 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-USP16 antibody (ab4853)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • Deubiquitinating enzyme 16
    • Human ubiquitin processing protease
    • MSTP039
    • Ubiquitin carboxyl-terminal hydrolase 16
    • Ubiquitin Specific peptidase 16
    • Ubiquitin Specific Protease 16
    • Ubiquitin thiolesterase 16
    • Ubiquitin-processing protease UBP-M
    • Ubiquitin-specific-processing protease 16
    • UBP M
    • UBP16_HUMAN
    • UBPM
    • usp16
    see all
  • 功能Specifically deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-10' of histone H3, and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
  • 组织特异性Present in all the tissues examined including fetal brain, lung, liver, kidney, and adult heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
  • 疾病相关Note=A chromosomal aberration involving USP16 is a cause of Chronic myelomonocytic leukemia. Inversion inv(21) (q21;q22) with RUNX1/AML1.
  • 序列相似性Belongs to the peptidase C19 family. USP16 subfamily.
    Contains 1 UBP-type zinc finger.
  • 结构域The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin.
  • 翻译后修饰Phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition. The phosphorylated form of the protein is also enzymatically active.
  • 细胞定位Nucleus.
  • Information by UniProt

Human USP16 peptide (ab23059)参考文献

ab23059 has not yet been referenced specifically in any publications.

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