概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列C-QETYSKQVTSQEP
    • 氨基酸167 to 179

相关产品

技术指标

Our Abpromise guarantee covers the use of ab22967 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-UBE2C antibody (ab3935)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • Cyclin selective ubiquitin carrier protein
    • dJ447F3.2
    • Mitotic specific ubiquitin conjugating enzyme
    • UB E2C
    • UBCH 10
    • UbcH10
    • UBE 2C
    • Ube2c
    • UBE2C_HUMAN
    • Ubiquitin carrier protein C
    • Ubiquitin carrier protein E2 C
    • Ubiquitin carrier protein E2C
    • Ubiquitin conjugating enzyme E2 C
    • Ubiquitin conjugating enzyme E2C
    • Ubiquitin protein ligase C
    • Ubiquitin-conjugating enzyme E2 C
    • Ubiquitin-protein ligase C
    see all
  • 功能Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.
  • 通路Protein modification; protein ubiquitination.
  • 序列相似性Belongs to the ubiquitin-conjugating enzyme family.
  • 翻译后修饰Autoubiquitinated by the APC/C complex, leading to its degradation by the proteasome. Its degradation plays a central role in APC/C regulation, allowing cyclin-A accumulation before S phase entry. APC/C substrates inhibit the autoubiquitination of UBE2C/UBCH10 but not its E2 function, hence APC/C remaining active until its substrates have been destroyed.
  • Information by UniProt

Human UBE2C peptide (ab22967)参考文献

ab22967 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab22967.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"